Pore size matters for potassium channel conductance
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Archivos
Fecha
2016-10
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
ROCKEFELLER UNIV PRESS
Nombre de Curso
Licencia CC
Licencia CC
Resumen
Ion channels are membrane proteins that mediate efficient ion transport across the hydrophobic core of cell membranes, an unlikely process in their absence. K+ channels discriminate K+ over cations with similar radii with extraordinary selectivity and display a wide diversity of ion transport rates, covering differences of two orders of magnitude in unitary conductance. The pore domains of large- and small-conductance K+ channels share a general architectural design comprising a conserved narrow selectivity filter, which forms intimate interactions with permeant ions, flanked by two wider vestibules toward the internal and external openings. In large- conductance K+ channels, the inner vestibule is wide, whereas in small-conductance channels it is narrow. Here we raise the idea that the physical dimensions of the hydrophobic internal vestibule limit ion transport in K+ channels, accounting for their diversity in unitary conductance.
Notas
Indexación: Web of Science; Scopus; Scielo.
Palabras clave
SHAKER K+ CHANNEL, LONG QT SYNDROME, QUATERNARY AMMONIUM BLOCKERS, BK CHANNELS, ION SELECTIVITY, MOLECULAR-DYNAMICS, PERMEATION PATHWAY, STRUCTURAL BASIS, ACTIVATION GATE, VOLTAGE SENSOR
Citación
Journal of General Physiology 148(4),277