Pore size matters for potassium channel conductance

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dc.contributor.authorNaranjo, D
dc.contributor.authorMoldenhauer, H
dc.contributor.authorPincuntureo, M
dc.contributor.authorDiaz-Franulic, I
dc.date.accessioned2017-04-28T18:49:23Z
dc.date.available2017-04-28T18:49:23Z
dc.date.issued2016-10
dc.descriptionIndexación: Web of Science; Scopus; Scielo.es
dc.description.abstractIon channels are membrane proteins that mediate efficient ion transport across the hydrophobic core of cell membranes, an unlikely process in their absence. K+ channels discriminate K+ over cations with similar radii with extraordinary selectivity and display a wide diversity of ion transport rates, covering differences of two orders of magnitude in unitary conductance. The pore domains of large- and small-conductance K+ channels share a general architectural design comprising a conserved narrow selectivity filter, which forms intimate interactions with permeant ions, flanked by two wider vestibules toward the internal and external openings. In large- conductance K+ channels, the inner vestibule is wide, whereas in small-conductance channels it is narrow. Here we raise the idea that the physical dimensions of the hydrophobic internal vestibule limit ion transport in K+ channels, accounting for their diversity in unitary conductance.es
dc.description.urihttp://jgp.rupress.org/content/148/4/277
dc.identifier.citationJournal of General Physiology 148(4),277es
dc.identifier.issn0022-1295
dc.identifier.otherDOI: 10.1085/jgp.201611625
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/3358
dc.language.isoenes
dc.publisherROCKEFELLER UNIV PRESSes
dc.subjectSHAKER K+ CHANNELes
dc.subjectLONG QT SYNDROMEes
dc.subjectQUATERNARY AMMONIUM BLOCKERSes
dc.subjectBK CHANNELSes
dc.subjectION SELECTIVITYes
dc.subjectMOLECULAR-DYNAMICSes
dc.subjectPERMEATION PATHWAYes
dc.subjectSTRUCTURAL BASISes
dc.subjectACTIVATION GATEes
dc.subjectVOLTAGE SENSORes
dc.titlePore size matters for potassium channel conductancees
dc.typeArtículoes
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