MMP-9 Levels in the Gingival Crevicular Fluid of Chilean Rosacea Patients

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dc.contributor.authorFernández, Javier
dc.contributor.authorJiménez, Constanza
dc.contributor.authorBenadof, Dafna
dc.contributor.authorMorales, Paulina
dc.contributor.authorAstorga, Jessica
dc.contributor.authorCáceres, Felipe
dc.contributor.authorHernández, Marcela
dc.contributor.authorFernández, Alejandra
dc.contributor.authorValenzuela, Fernando
dc.date.accessioned2023-07-11T17:01:57Z
dc.date.available2023-07-11T17:01:57Z
dc.date.issued2022-09
dc.descriptionIndexación: Scopuses
dc.description.abstractRosacea is a chronic inflammatory skin disease whose prevalence rates remain unknown in Chile. Laboratory benchmark testing for this disease is not useful, therefore, we aimed to evaluate the gingival crevicular fluid (GCF) levels of extracellular metalloproteinases (MMP)-2 and MMP-9 as novel rosacea biomarkers. We designed a cross-sectional study with a control group. Participants were systemically healthy adults (n = 20) and persons with rosacea (n = 18). We performed a periodontal evaluation and collected gingival crevicular fluid to measure MMP-2 and MMP-9 levels. Analysis showed mean and standard deviation of MMP-9 concentrations in the GCF for patients with rosacea was 764.52 ± 569.83 pg/mL; for healthy patients, it was 260.69 ± 170.43 pg/mL (p < 0.05). The diagnosis of rosacea was responsible for the levels of MMP-9 in the GCF (p < 0.05), as opposed to periodontitis, smoking, and age (p > 0.05). The Area under ROC for MMP-9 was 0.869 (95%, C.I: 0.719–0.956), with a sensitivity of 72.22% and specificity of 81.58% for the diagnosis of rosacea. We conclude that the quantification of MMP-9 in the GCF could be used as a biomarker of rosacea. Also, rosacea was responsible for increasing the levels of MMP-9 in the GCF independent of periodontal status. © 2022 by the authors.es
dc.identifier.citationInternational Journal of Molecular Sciences, Volume 23, Issue 17, September 2022, Article number 9858es
dc.identifier.doi10.3390/ijms23179858
dc.identifier.issn1661-6596
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/51544
dc.language.isoenes
dc.publisherMDPIes
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectbiomarkerses
dc.subjectgingival crevicular fluides
dc.subjectrosaceaes
dc.titleMMP-9 Levels in the Gingival Crevicular Fluid of Chilean Rosacea Patientses
dc.typeArtículoes
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