Gastroprotective activity of Parastrephia quadrangularis (Meyen), cabrera from the atacama desert

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dc.contributor.authorArdiles, A.
dc.contributor.authorBarrientos, R.
dc.contributor.authorSimirgiotis, M.J.
dc.contributor.authorBórquez, J.
dc.contributor.authorSepúlveda, B.
dc.contributor.authorAreche, C.
dc.date.accessioned2019-12-06T13:11:52Z
dc.date.available2019-12-06T13:11:52Z
dc.date.issued2018-09
dc.descriptionIndexación: Scopus.es
dc.descriptionChemicals and CAS Registry Numbers: alcohol, 64-17-5; hydrochloric acid, 7647-01-0; lansoprazole, 103577-45-3; Anti-Ulcer Agents; Benzofurans; Diterpenes, Clerodane; Ethanol; Hydrochloric Acid; Lansoprazole; Plant Extracts; tremetol
dc.description.abstractForty-three metabolites including several methoxylated flavonoids, tremetones, and ent-clerodane diterpenes were accurately identified for the first time in the ethanolic extract of P. quadrangularis by means of hyphenated UHPLC-quadrupole Orbitrap mass spectrometry, and seven isolated compounds were tested regarding gastroprotective activity using the HCl/EtOH-induced lesion model in mice. A new tremetone (compound 6) is reported based on spectroscopic evidence. The isolated clerodanes and tremetones showed gastroprotective activity in a mouse model, evidenced by compound 7 (p-coumaroyloxytremetone), which showed the highest gastroprotective activity (76%), which was higher than the control drug lansoprazole (72%). Our findings revealed that several constituents of this plant have gastroprotective activity, and particularly, p-coumaroyloxytremetone could be considered as a lead molecule to explore new gastroprotective agents. This plant is a rich source of biologically active tremetones and terpenoids which can support the ethnobotanical use of the plant. © 2018 MDPI AG. All rights reserved.es
dc.description.urihttps://www.mdpi.com/1420-3049/23/9/2361
dc.identifier.citationMolecules, 23(9), art. no. 2361.es
dc.identifier.issn1420-3049
dc.identifier.otherDOI: 10.3390/molecules23092361
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/11205
dc.language.isoenes
dc.publisherMDPI AGes
dc.subjectClerodaneses
dc.subjectEndemic plantses
dc.subjectGastric ulceres
dc.subjectGastroprotectivees
dc.subjectLC-MS/MSes
dc.subjectTremetoneses
dc.titleGastroprotective activity of Parastrephia quadrangularis (Meyen), cabrera from the atacama desertes
dc.typeArtículoes
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