Runt-Related Transcription Factor 2 Induction During Differentiation of Wharton's Jelly Mesenchymal Stem Cells to Osteoblasts Is Regulated by Jumonji AT-Rich Interactive Domain 1B Histone Demethylase

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dc.contributor.authorBusto, Francisco
dc.contributor.authorSepúlveda, Hugo
dc.contributor.authorPrieto, Catalina P.
dc.contributor.authorCarrasco, Margarita
dc.contributor.authorDíaz, Lorena
dc.contributor.authorPalma, José
dc.contributor.authorLattus, José
dc.contributor.authorMontecino, Martín
dc.contributor.authorPalma, Verónica
dc.date.accessioned2023-10-23T15:54:45Z
dc.date.available2023-10-23T15:54:45Z
dc.date.issued2017-12
dc.descriptionIndexación: Scopuses
dc.description.abstractNovel bone regeneration approaches aim to obtain immature osteoblasts from somatic stem cells. Umbilical cord Wharton's jelly mesenchymal stem cells (WJ-MSCs) are an ideal source for cell therapy. Hence, the study of mechanisms involved in WJ-MSC osteoblastic differentiation is crucial to exploit their developmental capacity. Here, we have assessed epigenetic control of the Runt-related transcription factor 2 (RUNX2) osteogenic master regulator gene in WJ-MSC. We present evidence indicating that modulation of RUNX2 expression through preventing Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase activity is relevant to enhance WJ-MSC osteoblastic potential. Hence, JARID1B loss of function in WJ-MSC results in increased RUNX2/p57 expression. Our data highlight JARID1B activity as a novel target to modulate WJ-MSC osteoblastic differentiation with potential applications in bone tissue engineering. Stem Cells 2017;35:2430–2441. © 2017 AlphaMed Presses
dc.description.urihttps://academic-oup-com.recursosbiblioteca.unab.cl/stmcls/article/36/4/631/6453103
dc.identifier.citationStem Cells Volume 35, Issue 12, Pages 2430 - 2441December 2017es
dc.identifier.doi10.1002/stem.2704
dc.identifier.issn1066-5099
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/53557
dc.language.isoenes
dc.publisherWiley-Blackwelles
dc.rights.licenseCC BY-NC-ND 4.0 DEED
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subjectEpigeneticses
dc.subjectMesenchymal stem cells (MSCs)es
dc.subjectOsteoblastses
dc.subjectUmbilical cordes
dc.titleRunt-Related Transcription Factor 2 Induction During Differentiation of Wharton's Jelly Mesenchymal Stem Cells to Osteoblasts Is Regulated by Jumonji AT-Rich Interactive Domain 1B Histone Demethylasees
dc.typeArtículoes
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