Active gains in brain using exercise during aging (AGUEDA): protocol for a randomized controlled trial

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dc.contributor.authorSolis-Urra, Patricio
dc.contributor.authorMolina-Hidalgo, Cristina
dc.contributor.authorGarcía-Rivero, Yolanda
dc.contributor.authorCosta-Rodriguez, Claudia
dc.contributor.authorMora-Gonzalez, Jose
dc.contributor.authorFernandez-Gamez, Beatriz
dc.contributor.authorOlvera-Rojas, Marcos
dc.contributor.authorCoca-Pulido, Andrea
dc.contributor.authorToval, Angel
dc.contributor.authorBellón, Darío
dc.contributor.authorSclafani, Alessandro
dc.contributor.authorMartín-Fuentes, Isabel
dc.contributor.authorTriviño-Ibañez, Eva María
dc.contributor.authorde Teresa, Carlos
dc.contributor.authorHuang, Haiqing
dc.contributor.authorGrove, George
dc.contributor.authorHillman, Charles H.
dc.contributor.authorKramer, Arthur F.
dc.contributor.authorCatena, Andrés
dc.contributor.authorOrtega, Francisco B.
dc.contributor.authorGómez-Río, Manuel
dc.contributor.authorErickson, Kirk I.
dc.contributor.authorEsteban-Cornejo, Irene
dc.date.accessioned2024-04-16T15:38:31Z
dc.date.available2024-04-16T15:38:31Z
dc.date.issued2023
dc.descriptionIndexación: Scopus.
dc.description.abstractAlzheimer’s disease is currently the leading cause of dementia and one of the most expensive, lethal and severe diseases worldwide. Age-related decline in executive function is widespread and plays a key role in subsequent dementia risk. Physical exercise has been proposed as one of the leading non-pharmaceutical approaches to improve executive function and ameliorate cognitive decline. This single-site, two-arm, single-blinded, randomized controlled trial (RCT) will include 90 cognitively normal older adults, aged 65–80 years old. Participants will be randomized to a 24-week resistance exercise program (3 sessions/week, 60 min/session, n = 45), or a wait-list control group (n = 45) which will be asked to maintain their usual lifestyle. All study outcomes will be assessed at baseline and at 24-weeks after the exercise program, with a subset of selected outcomes assessed at 12-weeks. The primary outcome will be indicated by the change in an executive function composite score assessed with a comprehensive neuropsychological battery and the National Institutes of Health Toolbox Cognition Battery. Secondary outcomes will include changes in brain structure and function and amyloid deposition, other cognitive outcomes, and changes in molecular biomarkers assessed in blood, saliva, and fecal samples, physical function, muscular strength, body composition, mental health, and psychosocial parameters. We expect that the resistance exercise program will have positive effects on executive function and related brain structure and function, and will help to understand the molecular, structural, functional, and psychosocial mechanisms involved. Copyright © 2023 Solis-Urra, Molina-Hidalgo, García-Rivero, Costa-Rodriguez, Mora-Gonzalez, Fernandez-Gamez, Olvera-Rojas, Coca-Pulido, Toval, Bellón, Sclafani, Martín-Fuentes, Triviño-Ibañez, de Teresa, Huang, Grove, Hillman, Kramer, Catena, Ortega, Gómez-Río, Erickson and Esteban-Cornejo.
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fnhum.2023.1168549/full
dc.identifier.citationFrontiers in Human Neuroscience. Volume 17. 2023. Article number 1168549
dc.identifier.doi10.3389/fnhum.2023.1168549
dc.identifier.issn1662-5161
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/56021
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.rights.licenseCC BY 4.0 DEED Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAlzheimer’s disease
dc.subjectAmyloid beta
dc.subjectBrain
dc.subjectExecutive function
dc.subjectExercise
dc.titleActive gains in brain using exercise during aging (AGUEDA): protocol for a randomized controlled trial
dc.typeArtículo
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