Alcohol volátil fenil etil alcohol (PEA) como agente antimicrobiano inocuo para el control de aggregatibacter actinomycetemcomitans
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Archivos
Fecha
2022
Profesor/a Guía
Facultad/escuela
Idioma
es
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Título del volumen
Editor
Universidad Andrés Bello
Nombre de Curso
Licencia CC
Licencia CC
Resumen
La enfermedad periodontal es una enfermedad multifactorial que a través de la
inflamación genera una disminución del tejido de soporte del diente, siendo una de las
enfermedades más prevalentes de la cavidad oral. Aggregatibacter
actinomycetencomitans (Aa) es un patógeno periodontal con variados factores de
virulencia, asociándose a una forma agresiva de la enfermedad. Variados alcoholes
volátiles han mostrado poseer actividades antimicrobianas frente a diversas bacterias.
Objetivo general: evaluar la efectividad del alcohol volátil alcohol fenietílico (PEA) como
agente antimicrobiano para el control de Aggregatibacter actinomycetemcomitans.
Metodología: se realizó un estudio experimental in vitro, transversal, descriptivo donde
se utilizaron cepas clínicas de Aa y la cepa tipo Y4 para probar la efectividad del alcohol
feniletílico (PEA) en distintas concentraciones y así evaluar la inhibición del crecimiento
bacteriano. Resultados: el alcohol PEA es efectivo contra Aggregatibacter
actinomycetemcomitans en concentraciones inhibitorias mínimas de 0.091 % PEADMSO y una concentración bactericida mínima de 0,364% PEA-DMSO Conclusión: Los
resultados de los estudios realizados confirmaron la actividad antimicrobiana del alcohol
PEA frente a Aggregatibacter actinomycetemcomitans, en concentraciones que podría
ser utilizado de forma inocua.
Periodontal disease is a multifactorial disease that through inflammation generates a decrease in the supporting tissue of the tooth, being one of the most prevalent diseases of the oral cavity. Aggregatibacter actinomycetencomitans (Aa) is a periodontal pathogen with various virulence factors, being associated with an aggressive form of the disease. Several volatile alcohols have been shown to possess antimicrobial activities against various bacteria. General objective: to evaluate the effectiveness of phenethyl alcohol volatile alcohol (PEA) as an antimicrobial agent for the control of Aggregatibacter actinomycetemcomitans. Methodology: an in vitro, cross-sectional, descriptive experimental study was carried out using clinical strains of Aa and strain type Y4 to test the effectiveness of phenylethyl alcohol (PEA) at different concentrations and thus evaluate the inhibition of bacterial growth. Results: PEA alcohol is effective against Aggregatibacter actinomycetemcomitans at minimum inhibitory concentrations of 0.091 % PEA-DMSO and a minimum bactericidal concentration of 0.364% PEA-DMSO Conclusion: The results of the studies performed confirmed the antimicrobial activity of PEA alcohol against Aggregatibacter actinomycetemcomitans, at concentrations that could be used safely.
Periodontal disease is a multifactorial disease that through inflammation generates a decrease in the supporting tissue of the tooth, being one of the most prevalent diseases of the oral cavity. Aggregatibacter actinomycetencomitans (Aa) is a periodontal pathogen with various virulence factors, being associated with an aggressive form of the disease. Several volatile alcohols have been shown to possess antimicrobial activities against various bacteria. General objective: to evaluate the effectiveness of phenethyl alcohol volatile alcohol (PEA) as an antimicrobial agent for the control of Aggregatibacter actinomycetemcomitans. Methodology: an in vitro, cross-sectional, descriptive experimental study was carried out using clinical strains of Aa and strain type Y4 to test the effectiveness of phenylethyl alcohol (PEA) at different concentrations and thus evaluate the inhibition of bacterial growth. Results: PEA alcohol is effective against Aggregatibacter actinomycetemcomitans at minimum inhibitory concentrations of 0.091 % PEA-DMSO and a minimum bactericidal concentration of 0.364% PEA-DMSO Conclusion: The results of the studies performed confirmed the antimicrobial activity of PEA alcohol against Aggregatibacter actinomycetemcomitans, at concentrations that could be used safely.
Notas
Tesis (Cirujano Dentista)
Palabras clave
Enfermedades Periodontales, Investigaciones, Aggregatibacter Actinomycetemcomitans, Agentes Antimicrobianos, Alcohol, Alcoholes Volátiles