Synthesis of nine safrole derivatives and their antiproliferative activity towards human cancer cells

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dc.contributor.authorEspinoza Catalán, Luis
dc.contributor.authorMadrid Villegas, Alejandro
dc.contributor.authorTaborga Liber, Lautaro
dc.contributor.authorVillena García, Joan
dc.contributor.authorCuellar Fritis, Mauricio
dc.contributor.authorCarrasco Altamirano, Héctor
dc.date.accessioned2013-10-22T18:50:38Z
dc.date.accessioned2016-05-24T20:22:41Z
dc.date.available2013-10-22T18:50:38Z
dc.date.available2016-05-24T20:22:41Z
dc.date.issued2010
dc.descriptionIndexación: Scielo
dc.description.abstractSafrole from sassafras oil (Ocoteapretiosa Mez., Lauraceae), is an abundant natural product showing interesting functionality and chemical structure. Starting from safrole, nine derivatives were prepared and assessed for antiproliferative effect using different human cell lines. The in vitro growth inhibition assay was based on the sulphorhodamine dye to quantify cell viability. Some safrole derivatives, (2E')-3-(3',4'-methylenedioxi)phenyl acrylaldehyde (3) and 4-allyl-5-nitrobenzene-1,2-diol (4) presented better antiproliferative effect than the parent compound on two breast cancer cell lines (MCF-7 and MDA-MB-231) and one human colorectal cancer cell line (DLD-1) with IC50 values of 55.0 + 7.11 uM, 37.5 +2.65 uM and 44.0 + 6.92 µM, respectively, without toxicity towards dermal human fibroblast (DHF cells).en
dc.description.urihttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200016&nrm=iso
dc.identifier.citationJournal of the Chilean Chemical Society, Vol. 55, N° 2, pp. 219-222, 2010.
dc.identifier.issnISSN: 0717-9707
dc.identifier.otherDOI: 10.4067/S0717-97072010000200016
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/1943
dc.language.isoen
dc.publisherSociedad Chilena de Química
dc.rights.holder© 2013 Sociedad Chilena de Química
dc.subjectAntiproliferative activity
dc.subjectSafrole derivatives
dc.subjectSynthesis
dc.titleSynthesis of nine safrole derivatives and their antiproliferative activity towards human cancer cells
dc.typeArtículo
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