Salivary Biomarkers for Oral Cancer Detection: An Exploratory Systematic Review

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dc.contributor.authorBastías, Daniel
dc.contributor.authorMaturana, Alejandro
dc.contributor.authorMarín, Constanza
dc.contributor.authorMartínez, René
dc.contributor.authorNiklander, Sven Eric
dc.date.accessioned2024-04-11T20:40:27Z
dc.date.available2024-04-11T20:40:27Z
dc.date.issued2024-03-05
dc.descriptionIndexación: Scopus.
dc.description.abstractDifferent efforts have been made to find better and less invasive methods for the diagnosis and prediction of oral cancer, such as the study of saliva as a source of biomarkers. The aim of this study was to perform a scoping review about salivary molecules that have been assessed as possible biomarkers for the diagnosis of oral squamous cell carcinoma (OSCC). A search was conducted using EBSCO, PubMed (MEDLINE), Scopus, and Web of Science. The research question was as follows: which molecules present in saliva have utility to be used as biomarkers for the early detection of oral cancer? Sixty-two studies were included. Over 100 molecules were assessed. Most of the markers were oriented towards the early diagnosis of OSCC and were classified based on their ability for detecting OSCC and oral potentially malignant disorders (OPMDs), OSCC outcome prediction, and the prediction of the malignant transformation of OPMDs. TNF-α, IL-1β, IL-6 IL-8, LDH, and MMP-9 were the most studied, with almost all studies reporting high sensitivity and specificity values. TNF-α, IL-1β, IL-6 IL-8, LDH, and MMP-9 are the most promising salivary biomarkers. However, more studies with larger cohorts are needed before translating the use of these biomarkers to clinical settings.
dc.description.urihttps://www-scopus-com.recursosbiblioteca.unab.cl/record/display.uri?eid=2-s2.0-85187653737&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=5f324f6cc1b30807997d97c7ede9789e&sot=aff&sdt=cl&cluster=scofreetoread%2c%22all%22%2ct&sl=61&s=AF-ID(%22Universidad+Andr%C3%A9s+Bello%22+60002636)+AND+SUBJAREA(CHEM)&relpos=1&citeCnt=0&searchTerm=
dc.identifier.citationInternational Journal of Molecular Sciences Open Access Volume 25, Issue 5March 2024 Article number 2634
dc.identifier.doi10.3390/ijms25052634
dc.identifier.issn16616596
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/55880
dc.language.isoen
dc.publisherMDPI
dc.rights.licenseCC BY 4.0 DEED Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectbiomarkers
dc.subjectmouth neoplasm
dc.subjectoral cancer
dc.subjectoral potentially malignant disorder
dc.subjectsaliva
dc.titleSalivary Biomarkers for Oral Cancer Detection: An Exploratory Systematic Review
dc.typeArtículo
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