Cytotoxic Effect of Puya chilensis Collected in Central Chile

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dc.contributor.authorEcheverria-Echeverria, C.
dc.contributor.authorValderrama-Villarroel, A.
dc.contributor.authorOrtega, M.
dc.contributor.authorContreras, R.
dc.contributor.authorZúñiga, G.
dc.contributor.authorAlvarado-Soto, L.
dc.contributor.authorRamírez-Tagle, R.
dc.date.accessioned2022-05-04T15:41:52Z
dc.date.available2022-05-04T15:41:52Z
dc.date.issued2022-04
dc.descriptionIndexación: Scopus.es
dc.description.abstractThis study sought to evaluate the pharmacological activity of metabolites isolated from the dried and lyophilized ethanol extracts as well as other solvent fractions of the currently endangered Puya chilensis Molina (Chagual) by analyzing their effects on a human hepatocellular carcinoma (HCC) cell line. We identified several active metabolites from Chagual extracts and two, in particular, carnosol, were found in all the prepared fractions. In addition, Chagual exhibited considerable cytotoxicity against the cancer cell line used in this study, with a half-maximal inhibitory concentration (IC50) of 0.44 ± 0.11 and 0.27 ± 0.04 after a 72-hour treatment and, therefore, has the potential for further investigation as a source of candidate therapeutic agents.es
dc.description.urihttps://journals.sagepub.com/doi/10.1177/1934578X221091671
dc.identifier.citationNatural Product Communications, Volume 17, Issue 4, April 2022es
dc.identifier.doi10.1177/1934578X221091671
dc.identifier.issn1934-578X
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/22454
dc.language.isoenes
dc.publisherSAGE Publications Inc.es
dc.rights.licenseAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)
dc.rights.urihttps://us.sagepub.com/en-us/nam/open-access-at-sage
dc.subjectbioactive nutrientses
dc.subjecthuman hepatocellular carcinomaes
dc.subjectmetaboliteses
dc.subjectPuya chilensises
dc.titleCytotoxic Effect of Puya chilensis Collected in Central Chilees
dc.typeArtículoes
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