Modulation of host adaptive immunity by hRSV proteins

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dc.contributor.authorEspinoza, Janyra A.
dc.contributor.authorBohmwald, Karen
dc.contributor.authorCéspedes, Pablo F.
dc.contributor.authorCéspedes, Pablo F.
dc.contributor.authorBueno, Susan M.
dc.contributor.authorKalergis, Alexis M.
dc.date.accessioned2023-07-13T21:19:53Z
dc.date.available2023-07-13T21:19:53Z
dc.date.issued2014
dc.descriptionIndexación: Scopus.es
dc.description.abstractGlobally, the human respiratory syncytial virus (hRSV) is the major cause of lower respiratory tract infections (LRTIs) in infants and children younger than 2 years old. Furthermore, the number of hospitalizations due to LRTIs has shown a sus tained increase every year due to the lack of effective vaccines against hRSV. Thus, this virus remains as a major public health and economic burden worldwide. The lung pathology devel oped in hRSV-infected humans is characterized by an exac erbated inflammatory and Th2 immune response. In order to rationally design new vaccines and therapies against this virus, several studies have focused in elucidating the interac tions between hRSV virulence factors and the host immune system. Here, we discuss the main features of hRSV biology, the processes involved in virus recognition by the immune system and the most relevant mechanisms used by this patho gen to avoid the antiviral host response.es
dc.description.urihttps://www-tandfonline-com.recursosbiblioteca.unab.cl/doi/full/10.4161/viru.32225?scroll=top&needAccess=true&role=tab
dc.identifier.citationVirulence. Volume 5, Issue 7, Pages 740 - 751. 2014es
dc.identifier.doi10.4161/viru.32225
dc.identifier.issn2150-5594
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/51661
dc.language.isoenes
dc.publisherLandes Biosciencees
dc.rights.licenseAtribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectRespiratory Syncytial Ciruses
dc.subjectVirulence Proteinses
dc.subjectInnate Immune Responsees
dc.subjectAdaptive Immune Responsees
dc.titleModulation of host adaptive immunity by hRSV proteinses
dc.typeArtículoes
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