Conventional and new proposals of GnRH therapy for ovarian, breast, and prostatic cancers

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dc.contributor.authorGarrido, Maritza P.
dc.contributor.authorHernandez, Andrea
dc.contributor.authorVega, Margarita
dc.contributor.authorAraya, Eyleen
dc.contributor.authorRomero, Carmen
dc.date.accessioned2024-03-28T22:05:19Z
dc.date.available2024-03-28T22:05:19Z
dc.date.issued2023
dc.descriptionIndexación: Scopus.
dc.description.abstractFor many years, luteinizing hormone-releasing hormone or gonadotropin-releasing hormone (GnRH) analogs have been used to treat androgen or estrogen-dependent tumors. However, emerging evidence shows that the GnRH receptor (GnRH-R) is overexpressed in several cancer cells, including ovarian, endometrial, and prostate cancer cells, suggesting that GnRH analogs could exert direct antitumoral actions in tumoral tissues that express GnRH-R. Another recent approach based on this knowledge was the use of GnRH peptides for developing specific targeted therapies, improving the delivery and accumulation of drugs in tumoral cells, and decreasing most side effects of current treatments. In this review, we discuss the conventional uses of GnRH analogs, together with the recent advances in GnRH-based drug delivery for ovarian, breast, and prostatic cancer cells. Copyright © 2023 Garrido, Hernandez, Vega, Araya and Romero.
dc.description.urihttps://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1143261/full
dc.identifier.citationFrontiers in Endocrinology. Volume 14. 2023. Article number 1143261
dc.identifier.doi10.3389/fendo.2023.1143261
dc.identifier.issn1664-2392
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/55485
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.rights.licenseCC BY 4.0 DEED Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBreast cancer
dc.subjectGnRH
dc.subjectOvarian cancer
dc.subjectProstatic cancer
dc.subjectTargeted therapy
dc.titleConventional and new proposals of GnRH therapy for ovarian, breast, and prostatic cancers
dc.typeArtículo
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