Hemichannels: new roles in astroglial function

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dc.contributor.authorOrellana, Juan A.
dc.contributor.authorStehberg, Jimmy
dc.date.accessioned2023-08-08T20:42:43Z
dc.date.available2023-08-08T20:42:43Z
dc.date.issued2014
dc.descriptionIndexación Scopus.es
dc.description.abstractThe role of astrocytes in brain function has evolved over the last decade, from support cells to active participants in the neuronal synapse through the release of “gliotransmitters.” Astrocytes express receptors for most neurotransmitters and respond to them through Ca2+ intracellular oscillations and propagation of intercellular Ca2+ waves. While such waves are able to propagate among neighboring astrocytes through gap junctions, thereby activating several astrocytes simultaneously, they can also trigger the release of gliotransmitters, including glutamate, d-serine, glycine, ATP, adenosine, or GABA. There are several mechanisms by which gliotransmitter release occurs, including functional hemichannels. These gliotransmitters can activate neighboring astrocytes and participate in the propagation of intercellular Ca2+ waves, or activate pre- and post-synaptic receptors, including NMDA, AMPA, and purinergic receptors. In consequence, hemichannels could play a pivotal role in astrocyte-to-astrocyte communication and astrocyte-to-neuron cross-talk. Recent evidence suggests that astroglial hemichannels are involved in higher brain functions including memory and glucose sensing. The present review will focus on the role of hemichannels in astrocyte-to-astrocyte and astrocyte-to neuron communication and in brain physiologyes
dc.identifier.citationFrontiers in Physiology. Volume 5 JUN. 2014. Article number Article 193es
dc.identifier.doi10.3389/fphys.2014.00193
dc.identifier.issn1664-042X
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/52338
dc.language.isoenes
dc.publisherFrontiers Research Foundationes
dc.rights.licenseAtribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAstrocyteses
dc.subjectHemichanneles
dc.subjectCalcium Waveses
dc.subjectTripartite Synapsees
dc.subjectConnexinses
dc.subjectBrain Functionses
dc.titleHemichannels: new roles in astroglial functiones
dc.typeArtículoes
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