Synthesis and antitumor activity of diterpenylhydroquinone derivatives of natural ent-labdanes

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dc.contributor.authorEspinoza Catalán, Luis
dc.contributor.authorBaeza Maturana, Evelyn
dc.contributor.authorCatalán Marín, Karen
dc.contributor.authorOsorio Olivares, Mauricio
dc.contributor.authorCarrasco Altamirano, Héctor
dc.contributor.authorCuellar Fritis, Mauricio
dc.contributor.authorVillena García, Joan
dc.date.accessioned2023-08-01T16:21:29Z
dc.date.available2023-08-01T16:21:29Z
dc.date.issued2010-09
dc.descriptionIndexación: Scopuses
dc.description.abstractTwo new compounds 2β-acetoxy-15-phenyl-(22,25-acetoxy)-ent-labda-8(17) , 13(E)-diene (9) and 2β-hydroxy-15-phenyl-(22,24,26-trimethoxy)-ent-labda- 8(17),13(E)-diene (10) have been prepared by an Electrophilic Aromatic Substitution (EAS) reaction between diterpenyl allylic alcohols and 1,4-hydroquinone or 1,3,5-trimethoxybenzene using BF3·Et 2O as a catalyst. These compounds, along with a series of natural ent-labdanes 3-8, have been evaluated for their in vitro cytotoxic activities against cultured human cancer cells of PC-3 and DU-145 human prostate cancer, MCF-7 and MDA-MB-231 breast carcinoma and dermal human fibroblasts (DHF). Some compounds displayed inhibition at μM IC50 values. © 2010 by the authors.es
dc.description.urihttps://www.mdpi.com/1420-3049/15/9/6502
dc.identifier.citationMolecules Volume 15, Issue 9, Pages 6502 - 6511September 2010es
dc.identifier.doi10.3390/molecules15096502
dc.identifier.issn1420-3049
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/52135
dc.language.isoenes
dc.publisherMDPIes
dc.rights.licenseAttribution 3.0 Unported (CC BY 3.0)
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.subjectAntitumoral activityes
dc.subjectDiterpenylhydroquinoneses
dc.subjectEnt-labdaneses
dc.titleSynthesis and antitumor activity of diterpenylhydroquinone derivatives of natural ent-labdaneses
dc.typeArtículoes
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