Hydrophobically modified polyelectrolytes as potential drugs reservoirs of n-alkyl-nitroimidazoles

Vista sencilla de ítem
dc.contributor.authorSalamanca, Constain H
dc.contributor.authorBarraza, Raúl G.
dc.contributor.authorAcevedo, Betsabé
dc.contributor.authorOlea, Andrés F.
dc.date.accessioned2013-10-22T18:50:53Z
dc.date.accessioned2016-05-24T20:25:01Z
dc.date.available2013-10-22T18:50:53Z
dc.date.available2016-05-24T20:25:01Z
dc.date.issued2007
dc.descriptionIndexación: Scielo
dc.description.abstractThe solubilization of three commercial drugs (ornindazole, metronidazole and tinidazole) and model compounds (N-alkyl-2-methyl-4-nitroimidazoles) on aggregates formed by anionic polyelectrolytes, carrying alkyl side chains of different length, have been investigated in aqueous solution at pH 3.0, 7.0 and 11.0. Potassium salts of poly(maleic acid-co-1-olefins), PA-nK2 with n ranging from 8 to 18, were used as micelle-forming polymers. The partition of these drugs between water and the hydrophobic microdomains provided by PA-nK2 was studied by the pseudo-phase model to determinate the distribution coefficient KS, and the standard free energy of transfer Δμºt. The results indicate that solubility of alkyl-nitroimidazoles on these polymer micelles depends moderately on the length of the alkyl chain, and therefore is mainly determined by the heterocyclic group. On the other hand, the solubilization of 1-hexyl-2-methyl-4-nitroimidazole increase with decreasing length of the side alkyl chain; i.e. KS follows the order PA-8K2 > PA-10K2 > PA-12K2 > PA-14K2 > PA-16K2 >PA-18K2.
dc.description.urihttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000100014&nrm=iso
dc.identifier.citationJournal of the Chilean Chemical Society, Vol. 52, pp. 1115-1119, 2007.
dc.identifier.issnISSN: 0717-9707
dc.identifier.otherDOI: 10.4067/S0717-97072007000100014
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/2036
dc.languageeng
dc.publisherSociedad Chilena de Química
dc.subjectPolyelectrolyte
dc.subjectMaleic copolymers
dc.subjectN-alkyl-nitroimidazoles
dc.subjectPartition
dc.subjectDrugs reservoirs
dc.titleHydrophobically modified polyelectrolytes as potential drugs reservoirs of n-alkyl-nitroimidazoles
dc.typeArtículo
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Constain_Hidrophobically.pdf
Tamaño:
412.62 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
FCE - Artículos de Revista