Physical Performance and Amyloid-β in Humans: A Systematic Review and Meta-Analysis of Observational Studies

Vista sencilla de ítem
dc.contributor.authorSolis-Urra, Patricio
dc.contributor.authorRodriguez-Ayllon, María
dc.contributor.authorÁlvarez-Ortega, Miriam
dc.contributor.authorMolina-Hidalgo, Cristina
dc.contributor.authorMolina-Garcia, Pablo
dc.contributor.authorArroyo-Ávila, Cristina
dc.contributor.authorGarcía-Hermoso, Antonio
dc.contributor.authorCollins, Audrey M.
dc.contributor.authorJain, Shivangi
dc.contributor.authorGispert, Juan Domingo
dc.contributor.authorLiu-Ambrose, Teresa
dc.contributor.authorOrtega, Francisco B.
dc.contributor.authorErickson, Kirk I.
dc.contributor.authorEsteban-Cornejo, Irene
dc.date.accessioned2024-08-06T15:26:43Z
dc.date.available2024-08-06T15:26:43Z
dc.date.issued2023-12-06
dc.descriptionIndexación: Scopus.
dc.description.abstractBackground: Accumulation of amyloid-β (Aβ) plaques is one of the main features of Alzheimer's disease (AD). Physical performance has been related to dementia risk and Aβ, and it has been hypothesized as one of the mechanisms leading to greater accumulation of Aβ. Yet, no evidence synthesis has been performed in humans. Objective: To investigate the association of physical performance with Aβ in humans, including Aβ accumulation on brain, and Aβ abnormalities measured in cerebrospinal fluid (CSF) and blood. Methods: A systematic review with multilevel meta-analysis was performed from inception to June 16th, 2022. Studies were eligible if they examined the association of physical performance with Aβ levels, including the measure of physical performance as a predictor and the measure of Aβ as an outcome in humans. Results: 7 articles including 2,619 participants were included in the meta-analysis. The results showed that physical performance was not associated with accumulation of Aβ in the brain (ES = 0.01; 95% CI -0.21 to 0.24; I2 = 69.9%), in the CSF (ES = -0.28; 95% CI -0.98 to 0.41; I2 = 91.0%) or in the blood (ES = -0.19; 95% CI -0.61 to 0.24; I2 = 99.75%). Significant heterogeneity was found across the results , which posed challenges in arriving at consistent conclusions; and the limited number of studies hindered the opportunity to conduct a moderation analysis. Conclusions: The association between physical performance and Aβ is inconclusive. This uncertainly arises from the limited number of studies, study design limitations, and heterogeneity of measurement approaches. More studies are needed to determine whether physical performance is related to Aβ levels in humans.
dc.description.urihttps://jyx.jyu.fi/bitstream/handle/123456789/93587/solis-meta-analysis.pdf;jsessionid=9C3D1AD10CA106D982058F42125504D3?sequence=2
dc.identifier.citationJournal of Alzheimer's Disease Volume 96, Issue 4, Pages 1427 - 1439 6 December 2023
dc.identifier.doi10.3233/AIAD230071
dc.identifier.issn1387-2877
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/59043
dc.language.isoen_US
dc.publisherIOS Press BV
dc.rights.licenseAtribución/Reconocimiento-NoComercial 4.0 Internacional
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/deed.es
dc.subjectAlzheimer's disease
dc.subjectamyloid
dc.subjectmeta-analysis
dc.subjectphysical performance
dc.titlePhysical Performance and Amyloid-β in Humans: A Systematic Review and Meta-Analysis of Observational Studies
dc.typeArtículo
Archivos
Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Developmental Dynamics - 2019 - Gundermann - Overexpression of Lin28a delays Xenopus metamorphosis and down‐regulates.pdf
Tamaño:
2.22 MB
Formato:
Adobe Portable Document Format
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
FEd - Artículos de Revista