Interleukin-4 Selectively Inhibits Interleukin-2 Secretion by Lipopolysaccharide-Activated Dendritic Cells

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dc.contributor.authorSauma, D.
dc.contributor.authorMichea, P.
dc.contributor.authorLennon-Dumenil, A.
dc.contributor.authorFierro, A.
dc.contributor.authorMorales, J.
dc.contributor.authorRosemblatt, M.
dc.contributor.authorBono, M.
dc.date.accessioned2021-06-15T21:29:14Z
dc.date.available2021-06-15T21:29:14Z
dc.date.issued2004-02
dc.descriptionIndexación: Scopus.es
dc.description.abstractDendritic cells (DCs) generated in vitro from bone marrow precursors using granulocyte-macrophage colony-stimulating factor (GM-CSF) secrete interleukin-2 (IL-2) upon activation, an event probably associated to the initiation of adaptive immune responses. Additionally, they produce IL-12, a cytokine related to T-cell polarization. To analyse the effect of IL-4 on DC differentiation and function, we assessed the capacity of murine bone marrow dendritic cells (BMDCs) differentiated with GM-CSF in the presence or absence of IL-4 to produce IL-2 and IL-12 upon lipopolysaccharide (LPS) activation. We found that although IL-4 enhanced DC IL-12p70 production, it strongly impaired IL-2 secretion by BMDCs. This inhibition, which depends on the presence of IL-4 during LPS activation, is DC specific, as IL-4 did not affect IL-2 secretion by T cells. Interestingly, inhibition of DC IL-2 production did not prevent DC priming of T lymphocytes. These results illustrate a new putative role for IL-4 on the regulation of the immune response and should help clarify the controversial reports on the effect of IL-4 on DCs.es
dc.description.urihttps://onlinelibrary.wiley.com/doi/full/10.1111/j.0300-9475.2004.01380.x
dc.identifier.citationScandinavian Journal of Immunology, Volume 59, Issue 2, Pages 183 - 189February 2004es
dc.identifier.doiDOI: 10.1111/j.0300-9475.2004.01380.x
dc.identifier.issn0300-9475
dc.identifier.uri
dc.language.isoenes
dc.publisherWileyes
dc.subjectNatural Killer Cellses
dc.subjectCell Differentiationes
dc.subjectCoculture Techniqueses
dc.subjectDendritic Cellses
dc.subjectFlow Cytometryes
dc.subjectInterleukin-12es
dc.subjectInterleukin-2es
dc.subjectInterleukin-4es
dc.subjectLipopolysaccharideses
dc.subjectLymphocyte Activationes
dc.titleInterleukin-4 Selectively Inhibits Interleukin-2 Secretion by Lipopolysaccharide-Activated Dendritic Cellses
dc.typeArtículoes
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