Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities

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dc.contributor.authorClemente-Suárez, Vicente Javier
dc.contributor.authorRedondo-Flórez, Laura
dc.contributor.authorBeltrán-Velasco, Ana Isabel
dc.contributor.authorRamos-Campo, Domingo Jesús
dc.contributor.authorBelinchón-deMiguel, Pedro
dc.contributor.authorMartinez-Guardado, Ismael
dc.contributor.authorDalamitros, Athanasios A.
dc.contributor.authorYáñez-Sepúlveda, Rodrigo
dc.contributor.authorMartín-Rodríguez, Alexandra
dc.contributor.authorTornero-Aguilera, José Francisco
dc.date.accessioned2023-11-07T13:35:33Z
dc.date.available2023-11-07T13:35:33Z
dc.date.issued2023-09
dc.descriptionIndexación: Scopus.es
dc.description.abstractMitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated in the pathogenesis of various brain diseases, including neurodegenerative disorders, stroke, and psychiatric illnesses. This review paper provides a comprehensive overview of the intricate relationship between mitochondria and brain disease, focusing on the underlying pathological mechanisms and exploring potential therapeutic opportunities. The review covers key topics such as mitochondrial DNA mutations, impaired oxidative phosphorylation, mitochondrial dynamics, calcium dysregulation, and reactive oxygen species generation in the context of brain disease. Additionally, it discusses emerging strategies targeting mitochondrial dysfunction, including mitochondrial protective agents, metabolic modulators, and gene therapy approaches. By critically analysing the existing literature and recent advancements, this review aims to enhance our understanding of the multifaceted role of mitochondria in brain disease and shed light on novel therapeutic interventions.es
dc.description.urihttps://www-scopus-com.recursosbiblioteca.unab.cl/record/display.uri?eid=2-s2.0-85172479847&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=3271b1f2e3093c41a16235165adce769&sot=aff&sdt=cl&cluster=scofreetoread%2c%22all%22%2ct&sl=61&s=AF-ID%28%22Universidad+Andr%c3%a9s+Bello%22+60002636%29+AND+SUBJAREA%28BIOC%29&relpos=16&citeCnt=1&searchTerm=
dc.identifier.citationBiomedicines, Open Access Volume 11, Issue 9 September 2023 Article number 2488es
dc.identifier.doi10.3390/biomedicines11092488
dc.identifier.issn22279059
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/53853
dc.language.isoenes
dc.publisherMDPIes
dc.rights.licenseCC BY 4.0 DEED
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBrain diseasees
dc.subjectMitochondriaes
dc.subjectMitochondrial DNA mutationses
dc.subjectMitochondrial dynamicses
dc.subjectMitochondrial protective agentses
dc.subjectNeurodegenerative disorderses
dc.subjectOxidative phosphorylationes
dc.subjectReactive oxygen specieses
dc.titleMitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunitieses
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