New catechol derivatives of safrole and their antiproliferative activity towards breast cancer cells

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dc.contributor.authorMadrid Villegas, Alejandro
dc.contributor.authorEspinoza Catalan, Luis
dc.contributor.authorMontenegro Venegas, Iván
dc.contributor.authorVillena García, Joan
dc.contributor.authorCarrasco Altamirano, Héctor
dc.date.accessioned2023-08-01T15:22:16Z
dc.date.available2023-08-01T15:22:16Z
dc.date.issued2011-06
dc.descriptionIndexación: Scopuses
dc.description.abstractCatechols were synthesized from safrole. Nine derivatives were prepared and assessed for antiproliferative effects using different human cell lines. The in vitro growth inhibition assay was based on the sulphorhodamine dye to quantify cell viability. The derivatives 4-allylbenzene-1,2-diol (3), 4 4-[3-(acetyloxy)propyl]-1,2-phenylene diacetate (6) and 4-[3-(acetyloxy)propyl]- 5-nitro-1,2-phenylene diacetate (10) showed higher cytotoxicity than the parent compound 2 in tests performed on two breast cancer cell lines (MCF-7 and MDA-MB-231). The IC50 values of 40.2 ± 6.9 μM, 5.9 ± 0.8 μM and 33.8 ± 4.9 μM, respectively, were obtained without toxicity towards dermal human fibroblast (DHF cells). © 2011 by the authors; licensee MDPI, Basel, Switzerland.es
dc.description.urihttps://www.mdpi.com/1420-3049/16/6/4632
dc.identifier.citationMolecules Volume 16, Issue 6, Pages 4632 - 4641June 2011es
dc.identifier.doi10.3390/molecules16064632
dc.identifier.issn1420-3049
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/52126
dc.language.isoenes
dc.publisherMDPIes
dc.rights.licenseAttribution 3.0 Unported (CC BY 3.0)
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.subjectAntiproliferative activityes
dc.subjectCatecholes
dc.subjectSynthesises
dc.titleNew catechol derivatives of safrole and their antiproliferative activity towards breast cancer cellses
dc.typeArtículoes
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