Research evaluating the effectiveness of dementia interventions in low- and middle-income countries: A systematic mapping of 340 randomised controlled trials

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dc.contributor.authorSalcher-Konrad, Maximilian
dc.contributor.authorShi, Cheng
dc.contributor.authorPatel, Disha
dc.contributor.authorMcDaid, David
dc.contributor.authorAstudillo-García, Claudia Iveth
dc.contributor.authorBobrow, Kirsten
dc.contributor.authorChoy, Jacky
dc.contributor.authorComas-Herrera, Adelina
dc.contributor.authorFry, Andra
dc.contributor.authorKnapp, Martin
dc.contributor.authorLeung, Dara Kiu Yi
dc.contributor.authorLopez-Ortega, Mariana
dc.contributor.authorLorenz-Dant, Klara
dc.contributor.authorMusyimi, Christine
dc.contributor.authorNdetei, David
dc.contributor.authorNguyen, Tuan Anh
dc.contributor.authorOliveira, Deborah
dc.contributor.authorPutra, Aditya
dc.contributor.authorVara, Alisha
dc.contributor.authorWong, Gloria
dc.contributor.authorNaci, Huseyin
dc.date.accessioned2024-11-20T13:00:30Z
dc.date.available2024-11-20T13:00:30Z
dc.date.issued2023-07
dc.descriptionIndexación: Scopus
dc.description.abstractObjectives: More people with dementia live in low- and middle-income countries (LMICs) than in high-income countries, but best-practice care recommendations are often based on studies from high-income countries. We aimed to map the available evidence on dementia interventions in LMICs. Methods: We systematically mapped available evidence on interventions that aimed to improve the lives of people with dementia or mild cognitive impairment (MCI) and/or their carers in LMICs (registered on PROSPERO: CRD42018106206). We included randomised controlled trials (RCTs) published between 2008 and 2018. We searched 11 electronic academic and grey literature databases (MEDLINE, EMBASE, PsycINFO, CINAHL Plus, Global Health, World Health Organization Global Index Medicus, Virtual Health Library, Cochrane CENTRAL, Social Care Online, BASE, MODEM Toolkit) and examined the number and characteristics of RCTs according to intervention type. We used the Cochrane risk of bias 2.0 tool to assess the risk of bias. Results: We included 340 RCTs with 29,882 (median, 68) participants, published 2008–2018. Over two-thirds of the studies were conducted in China (n = 237, 69.7%). Ten LMICs accounted for 95.9% of included RCTs. The largest category of interventions was Traditional Chinese Medicine (n = 149, 43.8%), followed by Western medicine pharmaceuticals (n = 109, 32.1%), supplements (n = 43, 12.6%), and structured therapeutic psychosocial interventions (n = 37, 10.9%). Overall risk of bias was judged to be high for 201 RCTs (59.1%), moderate for 136 (40.0%), and low for 3 (0.9%). Conclusions: Evidence-generation on interventions for people with dementia or MCI and/or their carers in LMICs is concentrated in just a few countries, with no RCTs reported in the vast majority of LMICs. The body of evidence is skewed towards selected interventions and overall subject to high risk of bias. There is a need for a more coordinated approach to robust evidence-generation for LMICs. © 2023 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd.
dc.description.urihttps://onlinelibrary-wiley-com.recursosbiblioteca.unab.cl/doi/10.1002/gps.5965
dc.identifier.citationInternational Journal of Geriatric Psychiatry. Volume 38, Issue. 7July 2023. Article number e5965
dc.identifier.doi10.1002/gps.5965
dc.identifier.issn0885-6230
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/62075
dc.language.isoen
dc.publisherJohn Wiley and Sons Ltd
dc.rights.licenseCC BY 4.0 Attribution 4.0 International Deed
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDementia
dc.subjectEvidence
dc.subjectGlobal South
dc.subjectHealth Policy
dc.subjectLMIC
dc.subjectLow- and middle-income
dc.subjectPsychosocial Interventions
dc.subjectSystematic Review
dc.subjectTraditional Chinese Medicine
dc.titleResearch evaluating the effectiveness of dementia interventions in low- and middle-income countries: A systematic mapping of 340 randomised controlled trials
dc.typeArtículo
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