Dissecting the role of redox signaling in neuronal development
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Archivos
Fecha
2016-05
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
Blackwell Publishing Ltd
Nombre de Curso
Licencia CC
Licencia CC
Resumen
The generation of abnormally high levels of reactive oxygen
species (ROS) is linked to cellular dysfunction, including
neuronal toxicity and neurodegeneration. However, physio logical ROS production modulates redox-sensitive roles of
several molecules such as transcription factors, signaling
proteins, and cytoskeletal components. Changes in the func tions of redox-sensitive proteins may be important for defining
key aspects of stem cell proliferation and differentiation,
neuronal maturation, and neuronal plasticity. In neurons, most
of the studies have been focused on the pathological impli cations of such modifications and only very recently their
essential roles in neuronal development and plasticity has
been recognized. In this review, we discuss the participation of
NADPH oxidases (NOXs) and a family of protein-methionine
sulfoxide oxidases, named molecule interacting with CasLs,
as regulated enzymatic sources of ROS production in
neurons, and describes the contribution of ROS signaling to
neurogenesis and differentiation, neurite outgrowth, and neu ronal plasticity.
Notas
Indexación: Scopus.
Palabras clave
NADPH Oxidase, MICAL, Reactive Oxygen Species, Neural Progenitor Cells, Neuronal Differentiation, NMDA Receptor
Citación
Journal of Neurochemistry. Volume 137, Issue 4, Pages 506 - 517. 1 May 2016
DOI
10.1111/jnc.13581