Dissecting the role of redox signaling in neuronal development

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dc.contributor.authorBórquez, Daniel A.
dc.contributor.authorUrrutia, Pamela J.
dc.contributor.authorWilson, Carlos
dc.contributor.authorVan Zundert, Brigitte
dc.contributor.authorNúñez, Marco Tulio
dc.contributor.authorGonzález-Billault, Christian
dc.date.accessioned2023-11-09T18:25:19Z
dc.date.available2023-11-09T18:25:19Z
dc.date.issued2016-05
dc.descriptionIndexación: Scopus.es
dc.description.abstractThe generation of abnormally high levels of reactive oxygen species (ROS) is linked to cellular dysfunction, including neuronal toxicity and neurodegeneration. However, physio logical ROS production modulates redox-sensitive roles of several molecules such as transcription factors, signaling proteins, and cytoskeletal components. Changes in the func tions of redox-sensitive proteins may be important for defining key aspects of stem cell proliferation and differentiation, neuronal maturation, and neuronal plasticity. In neurons, most of the studies have been focused on the pathological impli cations of such modifications and only very recently their essential roles in neuronal development and plasticity has been recognized. In this review, we discuss the participation of NADPH oxidases (NOXs) and a family of protein-methionine sulfoxide oxidases, named molecule interacting with CasLs, as regulated enzymatic sources of ROS production in neurons, and describes the contribution of ROS signaling to neurogenesis and differentiation, neurite outgrowth, and neu ronal plasticity.es
dc.description.urihttps://onlinelibrary-wiley-com.recursosbiblioteca.unab.cl/doi/10.1111/jnc.13581
dc.identifier.citationJournal of Neurochemistry. Volume 137, Issue 4, Pages 506 - 517. 1 May 2016es
dc.identifier.doi10.1111/jnc.13581
dc.identifier.issn0022-3042
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/53880
dc.language.isoenes
dc.publisherBlackwell Publishing Ltdes
dc.subjectNADPH Oxidasees
dc.subjectMICALes
dc.subjectReactive Oxygen Specieses
dc.subjectNeural Progenitor Cellses
dc.subjectNeuronal Differentiationes
dc.subjectNMDA Receptores
dc.titleDissecting the role of redox signaling in neuronal developmentes
dc.typeArtículoes
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