Evaluation of the extent of interstitial fibrosis in oral squamous cell carcinoma compared with normal oral mucosa and oral epithelial dysplasia

Vista sencilla de ítem
dc.contributor.authorYáñez, L.
dc.contributor.authorPeralta, C.
dc.contributor.authorSomarriva, C.
dc.contributor.authorFernández, A.
dc.date.accessioned2018-08-21T16:37:19Z
dc.date.available2018-08-21T16:37:19Z
dc.date.issued2018-02
dc.descriptionIndexación: Scopus.es_ES
dc.description.abstractObjective: To evaluate the extent of interstitial fibrosis in samples of normal oral mucosa (NOM), oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Materials and method: Descriptive study. Eighteen samples of NOM, 15 samples of OED, and 13 samples of OSCC were analyzed; all stained with Masson’s trichrome stain. The areas of greatest fibrosis underlying the normal, dysplastic, and malignant neoplastic oral epithelium were identified in order to determine the extent of interstitial fibrosis. Interstitial fibrosis was classified according to its proportion in the total image, being 0 (without fibrosis), +1 (1-25%), 2+ (26-50%), 3+ (51-75%) and +4 (76-100%). Variables were analyzed using the Kruskal-Wallis test and Dunn’s Pairwise post-hoc test. Results: The samples of NOM and OED did not present interstitial fibrosis (type 0) in the majority of the cases respectively. OSCC samples were characterized by an extension of type 2+ interstitial fibrosis in 45% of all cases of OSCC. The extent of interstitial fibrosis was different between NOM and OSCC (p<0.001), and between OED and OSCC (p<0.001). Conclusion: The extent of interstitial fibrosis is directly proportional to the malignization of the analyzed samples, being an adequate marker for OSCC.es_ES
dc.description.urihttp://www.joralres.com/index.php/JOR/article/view/401/386
dc.identifier.citationJournal of Oral Research, 7(2), pp. 51-54.es_ES
dc.identifier.issn0719-2479
dc.identifier.otherDOI: 10.17126/joralres.2018.016
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/6735
dc.language.isoenes_ES
dc.publisherUniversidad de Concepciones_ES
dc.subjectFibrosises_ES
dc.subjectOral neoplasiaes_ES
dc.subjectTumor microenvironmentes_ES
dc.titleEvaluation of the extent of interstitial fibrosis in oral squamous cell carcinoma compared with normal oral mucosa and oral epithelial dysplasiaes_ES
dc.typeArtículoes_ES
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Yanez_L_Evaluation_of_the_extent.pdf
Tamaño:
598.94 KB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN INGLES
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
FO - Artículos de Revista