Phenolic Profile and Cholinesterase Inhibitory Properties of Three Chilean Altiplano Plants: Clinopodium gilliesii (Benth.) Kuntze [Lamiaceae], Mutisia acuminata Ruiz & Pav. var. hirsuta (Meyen) Cabrera, and Tagetes multiflora (Kunth) [Asteraceae]

Vista sencilla de ítem
dc.contributor.authorFernández-Galleguillos, Carlos
dc.contributor.authorJiménez-Aspee, Felipe
dc.contributor.authorMieres-Castro, Daniel
dc.contributor.authorRodríguez-Núñez, Yeray A.
dc.contributor.authorGutiérrez, Margarita
dc.contributor.authorGuzmán, Luis
dc.contributor.authorEcheverría, Javier
dc.contributor.authorSandoval-Yañez, Claudia
dc.contributor.authorForero-Doria, Oscar
dc.date.accessioned2023-08-17T21:55:22Z
dc.date.available2023-08-17T21:55:22Z
dc.date.issued2023-02
dc.descriptionIndexación: Scopuses
dc.description.abstractThis research aimed to identify the phenolic profile and composition of the aerial parts of three native species used in traditional medicine in the Andean Altiplano of northern Chile: Clinopodium gilliesii (Benth.) Kuntze [Lamiaceae] (commonly known as Muña-Muña), Mutisia acuminata Ruiz & Pav. var. hirsuta (Meyen) Cabrera [Asteraceae] (commonly known as Chinchircoma), and Tagetes multiflora (Kunth), [Asteraceae] (commonly known as Gracilis), as well as to evaluate their potential inhibitory effects against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Polyphenolic enriched-extracts (PEEs) of the species were prepared and analyzed and the main components were quantified using HPLC-DAD. In total, 30 phenolic compounds were identified and quantified in all species, including simple phenolics, hydroxycinnamic acids, flavan-3-ols (monomers and polymers), flavanones, and flavonols. In addition, other main phenolics from the extracts were tentatively identified by ESI-MS-MS high-resolution analysis. T. multiflora extract showed the greatest anti-AChE and BChE activity in comparison with C. gilliesii and M. acuminata extracts, being the anti-AChE and BChE activity weak in all extracts in comparison to galantamine control. To comprise to better understand the interactions between cholinesterase enzymes and the main phenolics identified in T. multiflora, molecular docking analysis was conducted. © 2023 by the authors.es
dc.description.urihttps://www.mdpi.com/2223-7747/12/4/819
dc.identifier.citationPlants Volume 12, Issue 4February 2023 Article number 819es
dc.identifier.doi10.3390/plants12040819
dc.identifier.issn2223-7747
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/52610
dc.language.isoenes
dc.publisherMDPIes
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectCholinesterase inhibitiones
dc.subjectClinopodium gilliesiies
dc.subjectHPLC-DADes
dc.subjectMutisia acuminataes
dc.subjectPhenolic profilees
dc.subjectTagetes multifloraes
dc.titlePhenolic Profile and Cholinesterase Inhibitory Properties of Three Chilean Altiplano Plants: Clinopodium gilliesii (Benth.) Kuntze [Lamiaceae], Mutisia acuminata Ruiz & Pav. var. hirsuta (Meyen) Cabrera, and Tagetes multiflora (Kunth) [Asteraceae]es
dc.typeArtículoes
Archivos
Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Fernandez_C_Phenolic_and_Cholinesterase_Inhibitory_2023_Articles.pdf
Tamaño:
1.14 MB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN INGLES
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
FCE - Artículos de Revista