Photodegradation of nimodipine and felodipine in microheterogeneous systems

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dc.contributor.authorBrito, J.
dc.contributor.authorPozo, A.
dc.contributor.authorGarcía, C.
dc.contributor.authorNúñez-Vergara, L.
dc.contributor.authorMorales, J.
dc.contributor.authorGünther, G.
dc.contributor.authorPizarro, N.
dc.date.accessioned2023-07-12T14:18:58Z
dc.date.available2023-07-12T14:18:58Z
dc.date.issued2012
dc.descriptionIndexación: Scopus.es
dc.description.abstractThe photochemical behavior of nimodipine (NIMO) and felodipine (FELO), photolabile drugs widely used as antihypertensive calcium channel blockers, is studied in constrained media. Specifically, we are interested in the kinetic analysis of 4-aryl-1,4-dihydropyridine photodegradation processes when they are incorporated in biological-mimicking systems like micelles or liposomes. In order to establish if the nature of the head of surfactant (ionic or nonionic) could be important modulating the photo-reactivity of these drugs, we studied the photodegradation of NIMO and FELO incorporated in micelles formed with sodium dodecyl sulfate (SDS, anionic), dodecyl-pyridinium chloride (DPC, cationic) and mono lauryl sucrose ester (MLS, nonionic) as surfactants. Additionally, the results of the photodegradation of these compounds in liposomes were also included. The results clearly indicate that both dihydropyridines studied, NIMO and FELO, are located near to the interface, but the surface charge of micelles does not affect neither, the photodegradation rate constant nor the photodegradation products profile. The absence of singlet oxygen generation in micellar media is consistent with the proposition of these 4-aryl-1,4-dihidropyridines located near to the interface of the micelle, where a polar environment is sensed. In addition, the ethanol preferential location on membranes and dihydropyridine enhanced photodegradation by alcohol presence are interesting results to consider in future research.es
dc.description.urihttps://www-scielo-cl.recursosbiblioteca.unab.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000300025&lng=en&nrm=iso&tlng=en
dc.identifier.citationJournal of the Chilean Chemical Society, Volume 57, Issue 3, Pages 1313 - 1317, 2012es
dc.identifier.doi10.4067/S0717-97072012000300025
dc.identifier.issn0717-9324
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/51597
dc.language.isoenes
dc.publisherSociedad Chilena de Químicaes
dc.rights.licenseAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)
dc.subjectphotochemical behaviores
dc.subjectnimodipinees
dc.subjectfelodipinees
dc.subjectphotolabile drugses
dc.subjectantihypertensive calcium channel blockerses
dc.subjectkinetic analysises
dc.subject4-aryl-1,4-dihydropyridinees
dc.subjectbiological-mimicking systemses
dc.titlePhotodegradation of nimodipine and felodipine in microheterogeneous systemses
dc.typeArtículoes
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