A Higher Skeletal Muscle Mass and Lower Adiposity Phenotype Is Associated with Better Cardiometabolic Control in Adults with Hip and Knee Osteoarthritis: Results from the Chilean National Health Survey 2016–2017
dc.contributor.author | Guede-Rojas, Francisco | |
dc.contributor.author | Ibacache-Saavedra, Paulina | |
dc.contributor.author | Leal, María Inés | |
dc.contributor.author | Tuesta, Marcelo | |
dc.contributor.author | Durán-Marín, Cristóbal | |
dc.contributor.author | Carrasco-Marín, Fernanda | |
dc.contributor.author | Cigarroa, Igor | |
dc.contributor.author | Alvarez, Cristian | |
dc.contributor.author | Izquierdo, Mikel | |
dc.contributor.author | Delgado-Floody, Pedro | |
dc.date.accessioned | 2023-10-24T17:13:08Z | |
dc.date.available | 2023-10-24T17:13:08Z | |
dc.date.issued | 2023-09 | |
dc.description | Indexación: Scopus | es |
dc.description.abstract | Objective: This study aimed to (1) characterize cardiometabolic factors in self-reported hip and knee osteoarthritis (OAD) across four body composition phenotypes defined by muscle mass and adiposity, and (2) associate risk factors with diabetes and hypertension (HTN). Methods: A cross-sectional analysis of the Chilean National Health Survey 2016–17 (n = 4996) stratified participants into four groups: low skeletal muscle mass/high waist circumference (Low-SMM/High-WC), low SMM/low WC (Low-SMM/Low-WC), high SMM/high WC (High-SMM/High-WC), and high SMM/low WC (reference group). Each group was further divided into subgroups with or without diagnosed hip or knee OAD. The main outcomes were fasting plasma glucose, systolic (SBP)/diastolic (DBP) blood pressure (continuous outcomes), and other secondary factors such as cardiovascular risk (CVR). Results: In the hip OAD subgroup, the Low-SMM/High-WC groups had significantly higher SBP versus the reference value (145 vs. 127 mmHg, p < 0.0001, diff +18 mmHg). In the knee OAD subgroup, the Low-SMM/High-WC groups had significantly higher SBP versus the reference value (141 vs. 134 mmHg, p < 0.0001, diff +7 mmHg). The SBP showed a significant interaction between the group and OAD diagnosis (p = 0.007 hip OAD; p < 0.0001 knee OAD). Conclusions: Hip and knee OAD associates with elevated SBP/DBP in older adults. OAD groups showed an OR above 2 for diabetes, 2.7 for HTN, 4.5 for metabolic syndrome, and over 2 for moderate-to-high cardiovascular risk. OAD interacts substantially with cardiometabolic factors, especially in low muscle mass/high adiposity phenotypes. Lifestyle optimization of physical activity and nutrition to preserve muscle mass and mitigate adiposity is essential for cardiometabolic health promotion in OAD patients. © 2023 by the authors. | es |
dc.description.uri | https://www.mdpi.com/2072-6643/15/19/4263 | |
dc.identifier.citation | Nutrients Open Access Volume 15, Issue 19September 2023 Article number 4263 | es |
dc.identifier.doi | 10.3390/nu15194263 | |
dc.identifier.issn | 2072-6643 | |
dc.identifier.uri | https://repositorio.unab.cl/xmlui/handle/ria/53588 | |
dc.language.iso | en | es |
dc.publisher | MDPI | es |
dc.rights.license | Atribución 4.0 Internacional (CC BY 4.0) | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/deed.es | |
dc.subject | Arterial hypertension | es |
dc.subject | Body fat | es |
dc.subject | Diabetes | es |
dc.subject | Older adults | es |
dc.subject | Osteoarthritis | es |
dc.subject | Skeletal muscle mass | es |
dc.title | A Higher Skeletal Muscle Mass and Lower Adiposity Phenotype Is Associated with Better Cardiometabolic Control in Adults with Hip and Knee Osteoarthritis: Results from the Chilean National Health Survey 2016–2017 | es |
dc.type | Artículo | es |
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