Photodegradation of nimodipine and felodipine in microheterogeneous systems

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dc.contributor.authorBrito, Julio
dc.contributor.authorPozo, Andrés
dc.contributor.authorGarcía, Cristóbal
dc.contributor.authorNúñez-Vergara, Luis J.
dc.contributor.authorMorales, Javier
dc.contributor.authorGünther, Germán
dc.contributor.authorPizarro, Nancy
dc.date.accessioned2013-10-22T18:50:39Z
dc.date.accessioned2016-05-24T20:24:04Z
dc.date.available2013-10-22T18:50:39Z
dc.date.available2016-05-24T20:24:04Z
dc.date.issued2012
dc.descriptionIndexación: Web of Science; Scielo
dc.description.abstractThe photochemical behavior of nimodipine (NIMO) and felodipine (FELO), photolabile drugs widely used as antihypertensive calcium channel blockers, is studied in constrained media. Specifically, we are interested in the kinetic analysis of 4-aryl-1,4-dihydropyridine photodegradation processes when they are incorporated in biological-mimicking systems like micelles or liposomes. In order to establish if the nature of the head of surfactant (ionic or nonionic) could be important modulating the photo-reactivity of these drugs, we studied the photodegradation of NIMO and FELO incorporated in micelles formed with sodium dodecyl sulfate (SDS, anionic), dodecyl-pyridinium chloride (DPC, cationic) and mono lauryl sucrose ester (MLS, nonionic) as surfactants. Additionally, the results of the photodegradation of these compounds in liposomes were also included. The results clearly indicate that both dihydropyridines studied, NIMO and FELO, are located near to the interface, but the surface charge of micelles does not affect neither, the photodegradation rate constant nor the photodegradation products profile. The absence of singlet oxygen generation in micellar media is consistent with the proposition of these 4-aryl-1,4-dihidropyridines located near to the interface of the micelle, where a polar environment is sensed. In addition, the ethanol preferential location on membranes and dihydropyridine enhanced photodegradation by alcohol presence are interesting results to consider in future research.en
dc.description.urihttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000300025&nrm=iso
dc.identifier.citationJournal of the Chilean Chemical Society, Vol. 57, N° 3, pp. 1313-1317, 2012.
dc.identifier.issnISSN: 0717-9707
dc.identifier.otherDOI: 10.4067/S0717-97072012000300025
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/1950
dc.language.isoen
dc.publisherSociedad Chilena de Química
dc.rights.holder© 2013 Sociedad Chilena de Química
dc.subjectComportamiento fotoquímico
dc.subjectNimodipina (NIMO)
dc.subjectFelodipino (Felo)
dc.subjectFotodegradación
dc.subjectSistemas microheterogéneas
dc.titlePhotodegradation of nimodipine and felodipine in microheterogeneous systems
dc.typeArtículo
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