Periodontal disease and brain amyloid pathology in mild cognitive impairment

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dc.contributor.authorGil-Montoya J.A.
dc.contributor.authorGerez-Muñoz M.J.
dc.contributor.authorTriviño-Ibáñez E.
dc.contributor.authorCarrera-Muñoz I.
dc.contributor.authorBravo M.
dc.contributor.authorRashki M.
dc.contributor.authorSolis-Urra P.
dc.contributor.authorEsteban-Cornejo I.
dc.contributor.authorGómez-Río M.
dc.date.accessioned2024-11-14T15:57:14Z
dc.date.available2024-11-14T15:57:14Z
dc.date.issued2024
dc.descriptionIndexación: Scopus
dc.description.abstractIncreases in brain -amyloid protein (A) levels have been demonstrated in animal models following oral inoculation of periodontopathogens or their enzyme gingipain. We investigated the association between periodontitis and brain A protein levels in mild cognitive impairment (MCI). Methods: An observational study was designed. All participants underwent a periodontal examination and an amyloid-PET scan. Subsequently, the following groups were established: MCI and suspected Alzheimer disease (AD) (MCI/A+ group) (n = 45); MCI and suspected non-AD pathology (MCI/A— group) (n = 59); cognitively healthy elderly individuals with negative PET-amyloid scan results (non-MCI/A— group) (n = 60). Results: Patients with moderate-severe periodontitis had a higher risk of abnormal accumulation of A in the brain, with an odds ratio (OR) of 3.30 (95% confidence interval [CI], 1.30—8.26) when comparing patients from the MCI/A+ and MCI/A— groups, and an OR of 4.94 (95% CI, 1.65—14.84) when comparing the MCI/A+ group against the non-MCI/A— group. Conclusions: Our findings suggest that periodontal disease may be associated with anomalous accumulation of cerebral A protein in older people, independently of cognitive impairment.
dc.identifier.citationNeurologia 2024
dc.identifier.doi10.1016/j.nrl.2023.03.004
dc.identifier.issn0213-4853
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/61990
dc.language.isoen
dc.publisherSpanish Society of Neurology
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAlzheimer disease
dc.subjectAmyloid-PET scan
dc.subjectMild cognitive impairment
dc.subjectPeriodontal disease
dc.subjectβ-Amyloid
dc.titlePeriodontal disease and brain amyloid pathology in mild cognitive impairment
dc.title.alternativeEnfermedad periodontal y afección cerebral amiloide en deterioro cognitivo leve
dc.typeArtículo
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