Neurochemical and behavioral characterization of neuronal glutamate transporter EAAT3 heterozygous mice

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dc.contributor.authorGonzález, L.F.
dc.contributor.authorHenríquez-Belmar, F.
dc.contributor.authorDelgado-Acevedo, C.
dc.contributor.authorCisternas-Olmedo, M.
dc.contributor.authorArriagada, G.
dc.contributor.authorSotomayor-Zárate, R.
dc.contributor.authorMurphy, D.L.
dc.contributor.authorMoya, P.R.
dc.date.accessioned2018-07-23T15:59:56Z
dc.date.available2018-07-23T15:59:56Z
dc.date.issued2017
dc.descriptionIndexación: Scopus.es_ES
dc.description.abstractBACKGROUND: Obsessive-compulsive disorder (OCD) is a severe neuropsychiatric condition affecting 1-3% of the worldwide population. OCD has a strong genetic component, and the SLC1A1 gene that encodes neuronal glutamate transporter EAAT3 is a strong candidate for this disorder. To evaluate the impact of reduced EAAT3 expression in vivo, we studied male EAAT3 heterozygous and wild-type littermate mice using a battery of behavioral paradigms relevant to anxiety (open field test, elevated plus maze) and compulsivity (marble burying), as well as locomotor activity induced by amphetamine. Using high-performance liquid chromatography, we also determined tissue neurotransmitter levels in cortex, striatum and thalamus-brain areas that are relevant to OCD. RESULTS: Compared to wild-type littermates, EAAT3 heterozygous male mice have unaltered baseline anxiety-like, compulsive-like behavior and locomotor activity. Administration of acute amphetamine (5 mg/kg intraperitoneally) increased locomotion with no differences across genotypes. Tissue levels of glutamate, GABA, dopamine and serotonin did not vary between EAAT3 heterozygous and wild-type mice. CONCLUSIONS: Our results indicate that reduced EAAT3 expression does not impact neurotransmitter content in the corticostriatal circuit nor alter anxiety or compulsive-like behaviors.es_ES
dc.description.urihttps://biolres.biomedcentral.com/articles/10.1186/s40659-017-0138-3
dc.identifier.citationBiological Research. Volume 50, Issue 1, 19 September 2017, Page 29es_ES
dc.identifier.issn0717-6287
dc.identifier.otherDOI: 10.1186/s40659-017-0138-3
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/6346
dc.language.isoenes_ES
dc.publisherSociedad de Biología de Chilees_ES
dc.subjectEAAT3es_ES
dc.subjectNeuronal glutamate transporteres_ES
dc.subjectObsessive–compulsive disorderes_ES
dc.subjectSLC1A1es_ES
dc.titleNeurochemical and behavioral characterization of neuronal glutamate transporter EAAT3 heterozygous micees_ES
dc.typeArtículoes_ES
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