Regulatory T lymphocytes in periodontitis: a translational view

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dc.contributor.authorAlvarez, Carla
dc.contributor.authorRojas, Carolina
dc.contributor.authorRojas, Leticia
dc.contributor.authorCafferata, Emilio A.
dc.contributor.authorMonasterio, Gustavo
dc.contributor.authorVernal, Rolando
dc.date.accessioned2022-09-09T15:43:20Z
dc.date.available2022-09-09T15:43:20Z
dc.date.issued2018
dc.descriptionIndexación Scopuses
dc.description.abstractPeriodontitis is a chronic immuno-inflammatory disease in which the disruption of the balance between host and microbiota interactions is key to the onset and progression of the disease. The immune homeostasis associated with periodontal health requires a regulated immuno-inflammatory response, during which the presence of regulatory T cells (Tregs) is essential to ensure a controlled response that minimizes collateral tissue damage. Since Tregs modulate both innate and adaptive immunity, pathological conditions that may resolve by the acquisition of immuno-tolerance, such as periodontitis, may benefit by the use of Treg immunotherapy. In recent years, many strategies have been proposed to take advantage of the immuno-suppressive capabilities of Tregs as immunotherapy, including the ex vivo and in vivo manipulation of the Treg compartment. Ongoing research in both basic and translational studies let us gain a better understanding of the diversity of Treg subsets, their phenotypic plasticity, and suppressive functions, which can be used as a substrate for new immunotherapies. Certainly, as our knowledge of Treg biology increases, we will be capable to develop new therapies designed to enhance the stability and function of Tregs during periodontitis. © 2018 Carla Alvarez et al.es
dc.description.urihttps://www.hindawi.com/journals/mi/2018/7806912/
dc.identifier.citationMediators of Inflammation Volume 2018, 2018, Article number 7806912es
dc.identifier.doi10.1155/2018/7806912
dc.identifier.issn09629351
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/23823
dc.language.isoenes
dc.publisherHindawi Limitedes
dc.rights.licenseCC BY 4.0
dc.subjectCánceres
dc.subjectB-Lymphocyte Subsetes
dc.subjectInterleukin-10es
dc.titleRegulatory T lymphocytes in periodontitis: a translational viewes
dc.typeArtículoes
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