A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins

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dc.contributor.authorChoi, Won Ila
dc.contributor.authorKamaly, Nazilaa
dc.contributor.authorRiol-Blanco, Lorenab
dc.contributor.authorLee, In-Hyuna
dc.contributor.authorWu, Juna
dc.contributor.authorSwami, Archanaa
dc.contributor.authorVilos, Cristiana, c
dc.contributor.authorYameen, Basita
dc.contributor.authorYu, Mikyunga
dc.contributor.authorShi, Jinjuna
dc.contributor.authorTabas, Irad, e, f
dc.contributor.authorVon Andrian, Ulrich H.
dc.contributor.authorJon, Sangyongg
dc.contributor.authorFarokhzad, Omid C.
dc.date.accessioned2022-05-12T18:02:10Z
dc.date.available2022-05-12T18:02:10Z
dc.date.issued2014-11
dc.descriptionIndexación: Scopuses
dc.description.abstractProtein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo. © 2014 American Chemical Society.es
dc.description.urihttps://pubs-acs-org.recursosbiblioteca.unab.cl/doi/pdf/10.1021/nl502994y
dc.identifier.doi10.1021/nl502994y
dc.identifier.issn1530-6984
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/22505
dc.language.isoenes
dc.publisherNano Letterses
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectbiologicses
dc.subjectNanoparticleses
dc.subjectsolvent-freees
dc.subjecttherapeutic proteinses
dc.subjectthermospongees
dc.titleA solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteinses
dc.typeArtículoes
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Nano Letters Volume 14, Issue 11, Pages 6449 - 645512 November 2014
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