SYNTHESIS OF GERANYLHYDROQUINONE DERIVATIVES WITH POTENCIAL CYTOTOXIC ACTIVITY
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Archivos
Fecha
2012
Profesor/a Guía
Facultad/escuela
Idioma
english
Título de la revista
ISSN de la revista
Título del volumen
Editor
Sociedade Brasileira de Química
Nombre de Curso
Licencia CC
Licencia CC
Resumen
Natural geranylhydroquinone 1 and geranyl-p-methoxyphenol 2 were prepared by
Electrophilic Aromatic Substitution (EAS) reactions between geraniol and 1,4-hydroquinone or
p-methoxyphenol respectively, using BF3∙Et2O as a catalyst. Furthermore, natural geranylquinone 3,
geranyl-1,4-dimethoxyquinone 4 and the new geranyl-4-methoxyphenyl acetate 5 were obtained by chemical transformations of 1 and 2. The compounds were evaluated for their in vitro cytotoxicity activities against cultured human cancer cells of PC-3 human prostate cancer, MCF-7 and MDA-MB-231 breast carcinoma, and Dermal Human Fibroblasts DHF. IC50 values were in the µM range.
Notas
Indexación: Web of Science; Scielo
Palabras clave
Natural geranylhydroquinone, Electrophilic Aromatic Substitution, hydroquinone or p-methoxypheno, SYNTHESIS, Cytotoxic activity
Citación
Quím. Nova vol.35 no.3 São Paulo 2012