Effect of periodontal debridement plus systemic azithromycin in subjects with stage III periodontitis: a randomized controlled clinical trial

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dc.contributor.authorNavarrete, Mariely
dc.contributor.authorOñate, Héctor
dc.contributor.authorLoyola, Katarina
dc.contributor.authorOlivares, Pamela
dc.date.accessioned2023-08-23T16:03:12Z
dc.date.available2023-08-23T16:03:12Z
dc.date.issued2022-09
dc.descriptionIndexación: Scopus.es
dc.description.abstractAim: To evaluate the effect of the systemic administration of azi-thromycin (AZM) as an adjunct to non-surgical periodontal therapy (NSPT) on the clinical and microbiological variables of patients with periodontitis Material and Methods: Eighteen volunteers received NSPT combined with placebo or AZM (500 mg/day) for 3 days (n=9/group). They were monitored clinically for probing pocket depth (PPD), clinical attachment level (CAL), O'Leary index (OI), bleeding on probing (BoP) at baseline and during the first, third and sixth month and microbiologically, at baseline and at 3 and 6 months after therapy, by conventional polymerase chain reaction tests. Results: Fourteen patients completed the study (n=7/group). Differences statistically significant were observed among both groups. The experimental group presented: A PPD mean (p=0.04) significantly lower and PPD reduction (p=0.02), at 6-months post NSPT. Regarding changes (∆), at the third month post NSPT, there was a significant increase in the number of shallow sites (p<0.001) and a decrease in the intermediate sites (p<0.001). In addition, a significant decrease in the mean number of deep sites (p= 0.04) was detected at 6 months post treatment. There was also a significant decrease in periodontal index BoP at 1 (p=0.01), 3 (p<0.001) and 6 (p=0.01) months and OI at 3-and 6-months (p[removed]es
dc.description.urihttps://www.joralres.com/index.php/JOralRes/article/view/joralres.2022.051/1038
dc.identifier.citationJournal of Oral Research, Volume 11, Issue 5, Pages 1 - 16, September-October 2022es
dc.identifier.doi10.17126/joralres.2022.051
dc.identifier.issn0719-2460
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/52749
dc.language.isoenes
dc.publisherUniversidad de Concepciones
dc.rights.licenseAttribution 4.0 International (CC BY 4.0).
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAzithromycines
dc.subjectPeriodontal debridementes
dc.subjectPeriodontal diseaseses
dc.subjectPeriodontal indexes
dc.subjectPeriodontitises
dc.subjectRoot Planinges
dc.titleEffect of periodontal debridement plus systemic azithromycin in subjects with stage III periodontitis: a randomized controlled clinical triales
dc.title.alternativeEfecto del desbridamiento periodontal más azitromicina sistémica en sujetos con periodontitis estadio III: Un ensayo clínico controlado aleatorioes
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