Effects of six weeks of resistance-endurance training on microRNA-29 expression in the heart of ovariectomised rats
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Fecha
2018
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
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Título del volumen
Editor
Termedia Publishing House Ltd.
Nombre de Curso
Licencia CC
CC BY-NC-SA 4.0
Licencia CC
Resumen
Introduction: Heart disease risk rises with age. However, women’s symptoms become more pronounced following the onset of menopause. The aim of the present study was to evaluate the effects of six weeks of combined resistance-endurance (RE) training on microRNA-29 expression in the heart of ovariectomised rats. Material and methods: Thirty female Wistar rats were divided into three groups: 1) sham (SHAM); 2) ovariectomy (OVX); and 3) OVX with RE training (OVX + RE). The effects of these treatments on cardiac microRNA-29 expression were measured using real-time PCR. Data were analysed using a 2 × 3 ANOVA and Tukey post-hoc comparisons and presented as mean ±SEM. Results: Ovariectomy resulted in a significant down-regulation in the heart microRNA-29 gene expression of OVX (0.265 ±0.031 fold changes), OVX + RE (0.699 ±0.038 fold changes) in animals vs. sham animals (1 ±0 fold changes; all, p < 0.05) following six weeks of treatment. However, microRNA-29 expression in the OVX + RE group was significantly greater than in the OVX group (p < 0.05). Conclusions: Our findings suggest that the six weeks of regular RE training attenuate the reduction in heart muscle microRNA-29 expression observed in ovariectomised rates. If our findings carry over to humans, such an exercise regimen could be beneficial to the cardiovascular disease risk in women during menopause. © Termedia Publishing House Ltd. All rights reserved.
Notas
Indexación Scopus
Palabras clave
Ovariectomy, Exercise training, MicroRNA-29, Circulating Microrna, Cardiac Muscle Cell, Biomarkers
Citación
Przeglad Menopauzalny Volume 17, Issue 4, Pages 155 - 160 2018
DOI
10.5114/pm.2018.81737