Effects of six weeks of resistance-endurance training on microRNA-29 expression in the heart of ovariectomised rats

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dc.contributor.authorJourkesh, Morteza
dc.contributor.authorSoori, Rahman
dc.contributor.authorEarnest, Conrad
dc.contributor.author;Mirheidari, Lamia
dc.contributor.authorRavasi, Ali Asghar
dc.contributor.authorStannard, Stephen R.
dc.contributor.authorMonsalves-Alvarez, Matias
dc.date.accessioned2022-09-07T14:00:16Z
dc.date.available2022-09-07T14:00:16Z
dc.date.issued2018
dc.descriptionIndexación Scopuses
dc.description.abstractIntroduction: Heart disease risk rises with age. However, women’s symptoms become more pronounced following the onset of menopause. The aim of the present study was to evaluate the effects of six weeks of combined resistance-endurance (RE) training on microRNA-29 expression in the heart of ovariectomised rats. Material and methods: Thirty female Wistar rats were divided into three groups: 1) sham (SHAM); 2) ovariectomy (OVX); and 3) OVX with RE training (OVX + RE). The effects of these treatments on cardiac microRNA-29 expression were measured using real-time PCR. Data were analysed using a 2 × 3 ANOVA and Tukey post-hoc comparisons and presented as mean ±SEM. Results: Ovariectomy resulted in a significant down-regulation in the heart microRNA-29 gene expression of OVX (0.265 ±0.031 fold changes), OVX + RE (0.699 ±0.038 fold changes) in animals vs. sham animals (1 ±0 fold changes; all, p < 0.05) following six weeks of treatment. However, microRNA-29 expression in the OVX + RE group was significantly greater than in the OVX group (p < 0.05). Conclusions: Our findings suggest that the six weeks of regular RE training attenuate the reduction in heart muscle microRNA-29 expression observed in ovariectomised rates. If our findings carry over to humans, such an exercise regimen could be beneficial to the cardiovascular disease risk in women during menopause. © Termedia Publishing House Ltd. All rights reserved.es
dc.description.urihttps://www.termedia.pl/Effects-of-six-weeks-of-resistance-endurance-training-on-microRNA-29-expression-in-the-heart-of-ovariectomised-rats,4,34947,1,1.html
dc.identifier.citationPrzeglad Menopauzalny Volume 17, Issue 4, Pages 155 - 160 2018es
dc.identifier.doi10.5114/pm.2018.81737
dc.identifier.issn16438876
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/23774
dc.language.isoenes
dc.publisherTermedia Publishing House Ltd.es
dc.rights.licenseCC BY-NC-SA 4.0
dc.subjectOvariectomyes
dc.subjectExercise traininges
dc.subjectMicroRNA-29es
dc.subjectCirculating Micrornaes
dc.subjectCardiac Muscle Celles
dc.subjectBiomarkerses
dc.titleEffects of six weeks of resistance-endurance training on microRNA-29 expression in the heart of ovariectomised ratses
dc.typeArtículoes
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