Alloreactive regulatory T cells allow the generation of mixed chimerism and transplant tolerance
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Archivos
Fecha
2015-11
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
Frontiers Research Foundation
Nombre de Curso
Licencia CC
Atribución 4.0 Internacional (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.es
Resumen
The induction of donor-specific transplant tolerance is one of the main goals of modern immunology. Establishment of a mixed chimerism state in the transplant recipient has proven to be a suitable strategy for the induction of long-term allograft tolerance; however, current experimental recipient preconditioning protocols have many side effects, and are not feasible for use in future therapies. In order to improve the current mixed chimerism induction protocols, we developed a non-myeloablative bone-marrow transplant (NM-BMT) protocol using retinoic acid (RA)-induced alloantigen-specific Tregs, clinically available immunosuppressive drugs, and lower doses of irradiation. We demonstrate that RA-induced alloantigen-specific Tregs in addition to a NM-BMT protocol generates stable mixed chimerism and induces tolerance to allogeneic secondary skin allografts in mice. Therefore, the establishment of mixed chimerism through the use of donor-specific Tregs rather than non-specific immunosuppression could have a potential use in organ transplantation. © 2015 Ruiz, Maldonado, Hidalgo, Sauma, Rosemblatt and Bono.
Notas
Indexación: Scopus
Palabras clave
Alloreactive regulatory T cells, Mixed chimerism, Non-myeloablative conditioning, Organ transplantation, Transplant tolerance
Citación
Frontiers in Immunology Volume 6, Issue NOV2015 Article number 596
DOI
10.3389/fimmu.2015.00596