Alloreactive regulatory T cells allow the generation of mixed chimerism and transplant tolerance

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dc.contributor.authorRuiz, Paulina
dc.contributor.authorMaldonado, Paula
dc.contributor.authorHidalgo, Yessia
dc.contributor.authorSauma, Daniela
dc.contributor.authorRosemblatt, Mario
dc.contributor.authorBono, Maria Rosa
dc.date.accessioned2023-04-20T22:40:17Z
dc.date.available2023-04-20T22:40:17Z
dc.date.issued2015-11
dc.descriptionIndexación: Scopuses
dc.description.abstractThe induction of donor-specific transplant tolerance is one of the main goals of modern immunology. Establishment of a mixed chimerism state in the transplant recipient has proven to be a suitable strategy for the induction of long-term allograft tolerance; however, current experimental recipient preconditioning protocols have many side effects, and are not feasible for use in future therapies. In order to improve the current mixed chimerism induction protocols, we developed a non-myeloablative bone-marrow transplant (NM-BMT) protocol using retinoic acid (RA)-induced alloantigen-specific Tregs, clinically available immunosuppressive drugs, and lower doses of irradiation. We demonstrate that RA-induced alloantigen-specific Tregs in addition to a NM-BMT protocol generates stable mixed chimerism and induces tolerance to allogeneic secondary skin allografts in mice. Therefore, the establishment of mixed chimerism through the use of donor-specific Tregs rather than non-specific immunosuppression could have a potential use in organ transplantation. © 2015 Ruiz, Maldonado, Hidalgo, Sauma, Rosemblatt and Bono.es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fimmu.2015.00596/full
dc.identifier.citationFrontiers in Immunology Volume 6, Issue NOV2015 Article number 596es
dc.identifier.doi10.3389/fimmu.2015.00596
dc.identifier.issn1664-3224
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/48835
dc.language.isoenes
dc.publisherFrontiers Research Foundationes
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAlloreactive regulatory T cellses
dc.subjectMixed chimerismes
dc.subjectNon-myeloablative conditioninges
dc.subjectOrgan transplantationes
dc.subjectTransplant tolerancees
dc.titleAlloreactive regulatory T cells allow the generation of mixed chimerism and transplant tolerancees
dc.typeArtículoes
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