Antinociceptive interaction of Tramadol with Gabapentin in experimental mononeuropathic pain
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Archivos
Fecha
2016-08
Autores
Miranda, Hugo F.
Noriega, Viviana
Prieto, Juan Carlos
Zanetta, Pilar
Castillo, Rodrigo
Aranda, Nicolás
Sierralta, Fernando
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
Blackwell Publishing Ltd
Nombre de Curso
Licencia CC
Licencia CC
Resumen
Neuropathic pain is the result of injury to the nervous system, and different animal models have been established to meet the manifestations of neuropathy. The pharmacotherapy for neuropathic pain includes gabapentin and tramadol, but these are only partially effective when given alone. The aim of this study was to assess the antinociceptive interaction between both drugs using the isobolographic analysis and changes of the IL-1β concentration in a mouse model of neuropathic pain (partial sciatic nerve ligation or PSNL). The i.p. administration of gabapentin (5–100 mg/kg) or tramadol (12.5–100 mg/kg) displayed a dose-dependent antinociception in the hot plate assay of PSNL mice, and effects induced by gabapentin with tramadol were synergistic. Administration of gabapentin or tramadol reversed significantly the increase in the concentration of IL-1β induced by PSNL after either 7 or 14 days and their combination was significantly more potent in reversing the elevated concentration of IL-1β. The synergism obtained by the co-administration of gabapentin and tramadol is proposed to result from action on different mechanisms in pain pathways. Gabapentin or tramadol or their combination modulates the expression of pro-inflammatory cytokine, IL-1β, in a model of mice PSNL which could be due to an inhibition of glial function.
Notas
Indexación: Scopus.
Palabras clave
Neuropathic Pain, Gabapentin and Tramadol, Antinociceptive Interaction
Citación
Basic and Clinical Pharmacology and Toxicology. Volume 119, Issue 2, Pages 210 - 214. 1 August 2016
DOI
10.1111/bcpt.12567