The product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to β-lactam antibiotics in Gram-positive and Gram-negative bacteria
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Archivos
Fecha
2005-05-01
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
Elsevier
Nombre de Curso
Licencia CC
CC BY-NC-ND 4.0
ATRIBUCIÓN-NOCOMERCIAL-SINDERIVADAS 4.0 INTERNACIONAL
Deed
Licencia CC
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Resumen
We have characterized a natural isolate of Staphylococcus epidermidis resistant to heavy metals that carries a small 2391-bp plasmid, pSepCH, encoding the qacC gene. The S. epidermidis qacC gene confers resistance to a number of beta-lactam antibiotics and to ethidium bromide in its natural host and in Escherichia coli K12 and Salmonella enterica sv. Typhimurium. This is the first communication of a small multidrug resistance (SMR) pump involved in resistance to beta-lactam antibiotics. Experiments using tolC, ompW and ompD mutant strains of S. Typhimurium demonstrated that the beta-lactam antibiotic resistance conferred by this pump does not depend on these outer membrane proteins. (c) 2005 Elsevier SAS. All rights reserved.
Notas
INDEXACIÓN: WEB OF SCIENCE.
Palabras clave
multidrug resistance, Staphylococcus epidermidis, beta-lactam resistance, ethidium bromide, SMR
Citación
RESEARCH IN MICROBIOLOGY, Volume 156, Issue 4, Page, 472-477
DOI
10.1016/j.resmic.2005.01.002