Modified profile of matrix metalloproteinase 2 and 9 production by human fallopian tube epithelial cells after infection in vitro with neisseria gonorrhoeae
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Archivos
Fecha
2017
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
Oxford University Press
Nombre de Curso
Licencia CC
Atribución/Reconocimiento 4.0 Internacional
CC BY 4.0
Deed
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.es
Resumen
Epithelial shedding and scarring of fallopian tube mucosa are the main consequences of sexually transmitted Neisseria gonorrhoeae infection and probably involve an imbalance of host extracellular matrix components and their regulators such as matrix metalloproteinases (MMPs). In the current study, primary human fallopian tube epithelial cells were infected with N. gonorrhoeae, and MMP patterns were examined. Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed. Thus, MMP-9 in particular could play a role in tubal scarring in response to gonococcal infection. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society.
Notas
Indexación: Scopus
Palabras clave
Extracellular matrix, Human Fallopian tube epithelial cells, Matrix metalloproteinases, Neisseria gonorrhoeae
Citación
Journal of Infectious Diseases Volume 215, Issue 3, Pages 452 - 4552017
DOI
10.1093/infdis/jiw568