The Role of Omega-3 Polyunsaturated Fatty Acids and Their Lipid Mediators on Skeletal Muscle Regeneration: A Narrative Review

Skeletal muscle is the largest tissue in the human body, comprising approximately 40% of body mass. After damage or injury, a healthy skeletal muscle is often fully regenerated; however, with aging and chronic diseases, the regeneration process is usually incomplete, resulting in the formation of fibrotic tissue, infiltration of intermuscular adipose tissue, and loss of muscle mass and strength, leading to a reduction in functional performance and quality of life. Accumulating evidence has shown that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) and their lipid mediators (i.e., oxylipins and endocannabinoids) have the potential to enhance muscle regeneration by positively modulating the local and systemic inflammatory response to muscle injury. This review explores the process of muscle regeneration and how it is affected by acute and chronic inflammatory conditions, focusing on the potential role of n-3 PUFAs and their derivatives as positive modulators of skeletal muscle healing and regeneration. © 2023 by the authors.

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Indexación: Scopus
Funding: This research was funded by Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT), grant number 11220333 (SJ-V), grant number 11190971 (MF-O), grant number 1211962 (LP) and grant number 1221098 (RV).

Keywords

Endocannabinoids, Omega-3, Oxylipins, Regeneration, Regeneration, Skeletal Muscle

Citation

Nutrients. Volume 15, Issue 4. February 2023. Article number 871

DOI

10.3390/nu15040871

URI

https://repositorio.unab.cl/handle/ria/60165

Collections

FCR - Artículos de Revista

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