The Role of Omega-3 Polyunsaturated Fatty Acids and Their Lipid Mediators on Skeletal Muscle Regeneration: A Narrative Review

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dc.contributor.authorJannas-Vela, Sebastian
dc.contributor.authorEspinosa, Alejandra
dc.contributor.authorCandia, Alejandro A.
dc.contributor.authorFlores-Opazo, Marcelo
dc.contributor.authorPeñailillo, Luis
dc.contributor.authorValenzuela, Rodrigo
dc.date.accessioned2024-09-13T21:18:46Z
dc.date.available2024-09-13T21:18:46Z
dc.date.issued2023-02
dc.descriptionIndexación: Scopus
dc.descriptionFunding: This research was funded by Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT), grant number 11220333 (SJ-V), grant number 11190971 (MF-O), grant number 1211962 (LP) and grant number 1221098 (RV).
dc.description.abstractSkeletal muscle is the largest tissue in the human body, comprising approximately 40% of body mass. After damage or injury, a healthy skeletal muscle is often fully regenerated; however, with aging and chronic diseases, the regeneration process is usually incomplete, resulting in the formation of fibrotic tissue, infiltration of intermuscular adipose tissue, and loss of muscle mass and strength, leading to a reduction in functional performance and quality of life. Accumulating evidence has shown that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) and their lipid mediators (i.e., oxylipins and endocannabinoids) have the potential to enhance muscle regeneration by positively modulating the local and systemic inflammatory response to muscle injury. This review explores the process of muscle regeneration and how it is affected by acute and chronic inflammatory conditions, focusing on the potential role of n-3 PUFAs and their derivatives as positive modulators of skeletal muscle healing and regeneration. © 2023 by the authors.
dc.description.urihttps://www.mdpi.com/2072-6643/15/4/871
dc.identifier.citationNutrients. Volume 15, Issue 4. February 2023. Article number 871
dc.identifier.doi10.3390/nu15040871
dc.identifier.issn2072-6643
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/60165
dc.language.isoen
dc.publisherMDPI
dc.rights.licenseCC BY 4.0 Attribution 4.0 International Deed
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectEndocannabinoids
dc.subjectOmega-3
dc.subjectOxylipins
dc.subjectRegeneration
dc.subjectRegeneration
dc.subjectSkeletal Muscle
dc.titleThe Role of Omega-3 Polyunsaturated Fatty Acids and Their Lipid Mediators on Skeletal Muscle Regeneration: A Narrative Review
dc.typeArtículo
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