Hundred joules plasma focus device as a potential pulsed source for in vitro cancer cell irradiation

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dc.contributor.authorJain, J.
dc.contributor.authorMoreno, J.
dc.contributor.authorAndaur, R.
dc.contributor.authorArmisen, R.
dc.contributor.authorMorales, D.
dc.contributor.authorMarcelain, K.
dc.contributor.authorAvaria, G.
dc.contributor.authorBora, B.
dc.contributor.authorDavis, S.
dc.contributor.authorPavez, C.
dc.contributor.authorSoto, L.
dc.date.accessioned2018-02-01T20:02:20Z
dc.date.available2018-02-01T20:02:20Z
dc.date.issued2017-08
dc.descriptionIndexación: Web of Science; Scopus.es_CL
dc.description.abstractPlasma focus devices may arise as useful source to perform experiments aimed to study the effects of pulsed radiation on human cells in vitro. In the present work, a table top hundred joules plasma focus device, namely "PF-400J", was adapted to irradiate colorectal cancer cell line, DLD-1. For pulsed x-rays, the doses (energy absorbed per unit mass, measured in Gy) were measured using thermoluminescence detectors (TLD-100 dosimeters). The neutron fluence and the average energy were used to estimate the pulsed neutron doses. Fifty pulses of x-rays (0.12 Gy) and fifty pulses of neutrons (3.5 μGy) were used to irradiate the cancer cells. Irradiation-induced DNA damage and cell death were assessed at different time points after irradiation. Cell death was observed using pulsed neutron irradiation, at ultralow doses. Our results indicate that the PF-400J can be used for in vitro assessment of the effect of pulsed radiation in cancer cell research.es_CL
dc.description.urihttp://recursosbiblioteca.unab.cl:2296/doi/pdf/10.1063/1.4994655
dc.identifier.citationAIP Advances. Volume 7, Issue 8, 1 August 2017, Article number 085121es_CL
dc.identifier.issn2158-3226
dc.identifier.otherDOI: 10.1063/1.4994655
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/5243
dc.language.isoenes_CL
dc.publisherAmerican Institute of Physics Inc.es_CL
dc.subjectBEAM EMISSIONes_CL
dc.subjectENERGYes_CL
dc.titleHundred joules plasma focus device as a potential pulsed source for in vitro cancer cell irradiationes_CL
dc.typeArtículoes_CL
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