Flavonoids in microheterogeneous media, relationship between their relative location and their reactivity towards singlet oxygen
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Fecha
2015-06
Profesor/a Guía
Facultad/escuela
Idioma
en
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Título del volumen
Editor
Public Library of Science
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Licencia CC
Atribución 4.0 Internacional (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.es
Resumen
In this work, the relationship between the molecular structure of three flavonoids (kaempferol, quercetin and morin), their relative location in microheterogeneous media (liposomes and erythrocyte membranes) and their reactivity against singlet oxygen was studied. The changes observed in membrane fluidity induced by the presence of these flavonoids and the influence of their lipophilicity/hydrophilicity on the antioxidant activity in lipid membranes were evaluated by means of fluorescent probes such as Laurdan and diphenylhexatriene (DPH). The small differences observed for the value of generalized polarization of Laurdan (GP) curves in function of the concentration of flavonoids, indicate that these three compounds promote similar alterations in liposomes and erythrocyte membranes. In addition, these compounds do not produce changes in fluorescence anisotropy of DPH, discarding their location in deeper regions of the lipid bilayer. The determined chemical reactivity sequence is similar in all the studied media (kaempferol < quercetin < morin). Morin is approximately 10 times more reactive than quercetin and 20 to 30 times greater than kaempferol, depending on the medium. Copyright: © 2015 Günther et al.
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Indexación: Scopus
Palabras clave
Chlorpromazine, Lipid, Flunitrazepam
Citación
PLoS ONE Volume 10, Issue 622 June 2015 Article number e0129749
DOI
10.1371/journal.pone.0129749