Flavonoids in microheterogeneous media, relationship between their relative location and their reactivity towards singlet oxygen

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dc.contributor.authorGünther, Germán
dc.contributor.authorBerrîos, Eduardo
dc.contributor.authorPizarro, Nancy
dc.contributor.authorValdés, Karina
dc.contributor.authorMontero, Guillermo
dc.contributor.authorArriagada, Francisco
dc.contributor.authorMorales, Javier
dc.date.accessioned2023-05-11T18:30:51Z
dc.date.available2023-05-11T18:30:51Z
dc.date.issued2015-06
dc.descriptionIndexación: Scopuses
dc.description.abstractIn this work, the relationship between the molecular structure of three flavonoids (kaempferol, quercetin and morin), their relative location in microheterogeneous media (liposomes and erythrocyte membranes) and their reactivity against singlet oxygen was studied. The changes observed in membrane fluidity induced by the presence of these flavonoids and the influence of their lipophilicity/hydrophilicity on the antioxidant activity in lipid membranes were evaluated by means of fluorescent probes such as Laurdan and diphenylhexatriene (DPH). The small differences observed for the value of generalized polarization of Laurdan (GP) curves in function of the concentration of flavonoids, indicate that these three compounds promote similar alterations in liposomes and erythrocyte membranes. In addition, these compounds do not produce changes in fluorescence anisotropy of DPH, discarding their location in deeper regions of the lipid bilayer. The determined chemical reactivity sequence is similar in all the studied media (kaempferol < quercetin < morin). Morin is approximately 10 times more reactive than quercetin and 20 to 30 times greater than kaempferol, depending on the medium. Copyright: © 2015 Günther et al.es
dc.description.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129749
dc.identifier.citationPLoS ONE Volume 10, Issue 622 June 2015 Article number e0129749es
dc.identifier.doi
dc.identifier.doi10.1371/journal.pone.0129749
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/49546
dc.language.isoenes
dc.publisherPublic Library of Sciencees
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectChlorpromazinees
dc.subjectLipides
dc.subjectFlunitrazepames
dc.titleFlavonoids in microheterogeneous media, relationship between their relative location and their reactivity towards singlet oxygenes
dc.typeArtículoes
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