Theoretical and experimental approaches aimed at drug design targeting neurodegenerative diseases
No hay miniatura disponible
Archivos
Fecha
2019-12
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
MDPI AG
Nombre de Curso
Licencia CC
Atribution 4.0 International (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.es
Resumen
In recent years, green chemistry has been strengthening, showing how basic and applied
sciences advance globally, protecting the environment and human health. A clear example of this
evolution is the synergy that now exists between theoretical and computational methods to design
new drugs in the most efficient possible way, using the minimum of reagents and obtaining the
maximum yield. The development of compounds with potential therapeutic activity against multiple
targets associated with neurodegenerative diseases/disorders (NDD) such as Alzheimer’s disease
is a hot topic in medical chemistry, where different scientists from various disciplines collaborate
to find safe, active, and effective drugs. NDD are a public health problem, affecting mainly the
population over 60 years old. To generate significant progress in the pharmacological treatment
of NDD, it is necessary to employ different experimental strategies of green chemistry, medical
chemistry, and molecular biology, coupled with computational and theoretical approaches such as
molecular simulations and chemoinformatics, all framed in the rational drug design targeting NDD.
Here, we review how green chemistry and computational approaches have been used to develop new
compounds with the potential application against NDD, as well as the challenges and new directions
of the drug development multidisciplinary process.
Notas
Indexación: Scopus.
Palabras clave
Green Chemistry, Drug Design, Neurodegenerative Diseases, Molecular Modeling, Medical Chemistry, Chemoinformatics
Citación
Processes Volume 7, Issue 121 December 2019 Article number 940
DOI
DOI: 10.3390/PR7120940