Theoretical and experimental approaches aimed at drug design targeting neurodegenerative diseases

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dc.contributor.authorMorales-Navarro, Samuel
dc.contributor.authorPrent-Peñaloza, Luis
dc.contributor.authorRodríguez Núñez, Yeray A.
dc.contributor.authorSánchez-Aros, Laura
dc.contributor.authorForero-Doria, Oscar
dc.contributor.authorGonzález, Wendy
dc.contributor.authorCampilllo, Nuria E.
dc.contributor.authorReyes-Parada, Miguel
dc.contributor.authorMartínez, Ana
dc.contributor.authorRamírez, David
dc.date.accessioned2023-04-25T14:48:35Z
dc.date.available2023-04-25T14:48:35Z
dc.date.issued2019-12
dc.descriptionIndexación: Scopus.es
dc.description.abstractIn recent years, green chemistry has been strengthening, showing how basic and applied sciences advance globally, protecting the environment and human health. A clear example of this evolution is the synergy that now exists between theoretical and computational methods to design new drugs in the most efficient possible way, using the minimum of reagents and obtaining the maximum yield. The development of compounds with potential therapeutic activity against multiple targets associated with neurodegenerative diseases/disorders (NDD) such as Alzheimer’s disease is a hot topic in medical chemistry, where different scientists from various disciplines collaborate to find safe, active, and effective drugs. NDD are a public health problem, affecting mainly the population over 60 years old. To generate significant progress in the pharmacological treatment of NDD, it is necessary to employ different experimental strategies of green chemistry, medical chemistry, and molecular biology, coupled with computational and theoretical approaches such as molecular simulations and chemoinformatics, all framed in the rational drug design targeting NDD. Here, we review how green chemistry and computational approaches have been used to develop new compounds with the potential application against NDD, as well as the challenges and new directions of the drug development multidisciplinary process.es
dc.description.urihttps://www.mdpi.com/2227-9717/7/12/940
dc.identifier.citationProcesses Volume 7, Issue 121 December 2019 Article number 940es
dc.identifier.doiDOI: 10.3390/PR7120940
dc.identifier.issn2227-9717
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/48905
dc.language.isoenes
dc.publisherMDPI AGes
dc.rights.licenseAtribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectGreen Chemistryes
dc.subjectDrug Designes
dc.subjectNeurodegenerative Diseaseses
dc.subjectMolecular Modelinges
dc.subjectMedical Chemistryes
dc.subjectChemoinformaticses
dc.titleTheoretical and experimental approaches aimed at drug design targeting neurodegenerative diseaseses
dc.typeArtículoes
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