Neuro-Vulnerability in Energy Metabolism Regulation: A Comprehensive Narrative Review

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dc.contributor.authorClemente-Suárez, Vicente Javier
dc.contributor.authorBeltrán-Velasco, Ana Isabel
dc.contributor.authorRedondo-Flórez, Laura
dc.contributor.authorMartín-Rodríguez, Alexandra
dc.contributor.authorYáñez-Sepúlveda, Rodrigo
dc.contributor.authorTornero-Aguilera, José Francisco
dc.date.accessioned2024-11-20T18:56:54Z
dc.date.available2024-11-20T18:56:54Z
dc.date.issued2023-07
dc.descriptionIndexación: Scopus
dc.description.abstractThis comprehensive narrative review explores the concept of neuro-vulnerability in energy metabolism regulation and its implications for metabolic disorders. The review highlights the complex interactions among the neural, hormonal, and metabolic pathways involved in the regulation of energy metabolism. The key topics discussed include the role of organs, hormones, and neural circuits in maintaining metabolic balance. The review investigates the association between neuro-vulnerability and metabolic disorders, such as obesity, insulin resistance, and eating disorders, considering genetic, epigenetic, and environmental factors that influence neuro-vulnerability and subsequent metabolic dysregulation. Neuroendocrine interactions and the neural regulation of food intake and energy expenditure are examined, with a focus on the impact of neuro-vulnerability on appetite dysregulation and altered energy expenditure. The role of neuroinflammation in metabolic health and neuro-vulnerability is discussed, emphasizing the bidirectional relationship between metabolic dysregulation and neuroinflammatory processes. This review also evaluates the use of neuroimaging techniques in studying neuro-vulnerability and their potential applications in clinical settings. Furthermore, the association between neuro-vulnerability and eating disorders, as well as its contribution to obesity, is examined. Potential therapeutic interventions targeting neuro-vulnerability, including pharmacological treatments and lifestyle modifications, are reviewed. In conclusion, understanding the concept of neuro-vulnerability in energy metabolism regulation is crucial for addressing metabolic disorders. This review provides valuable insights into the underlying neurobiological mechanisms and their implications for metabolic health. Targeting neuro-vulnerability holds promise for developing innovative strategies in the prevention and treatment of metabolic disorders, ultimately improving metabolic health outcomes. © 2023 by the authors.
dc.description.urihttps://www.mdpi.com/2072-6643/15/14/3106
dc.identifier.citationNutrients. Volume 15, Issue 14. July 2023. Article number 3106
dc.identifier.doi10.3390/nu15143106
dc.identifier.issn2072-6643
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/62088
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.rights.licenseCC BY 4.0 Attribution 4.0 International Deed
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectEating Disorders
dc.subjectEnergy Metabolism
dc.subjectMetabolic Disorders
dc.subjectNeuro-Vulnerability
dc.subjectNeurobiological Mechanisms
dc.subjectNeuroendocrine Interactions
dc.subjectNeuroimaging Techniques
dc.subjectNeuroinflammation
dc.subjectObesity
dc.titleNeuro-Vulnerability in Energy Metabolism Regulation: A Comprehensive Narrative Review
dc.typeArtículo
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