Structural Characterization, DFT Calculation, NCI, Scan-Rate Analysis and Antifungal Activity against Botrytis cinerea of (E)-2-{[(2-Aminopyridin-2-yl)imino]-methyl}-4,6-di-tert-butylphenol (Pyridine Schiff Base)

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dc.contributor.authorCarreño, Alexander
dc.contributor.authorPaéz-Hernández, Dayán
dc.contributor.authorCantero-López, Plinio
dc.contributor.authorZúñiga, César
dc.contributor.authorNevermann, Jan
dc.contributor.authorRamírez-Osorio, Angélica
dc.contributor.authorGacituá, Manuel
dc.contributor.authorOyarzún, Poldie
dc.contributor.authorSaéz-Cortez, Felipe
dc.contributor.authorPolanco, Rubén
dc.contributor.authorOtero, Carolina
dc.contributor.authorFuentes, Juan A.
dc.date.accessioned2023-04-04T18:12:19Z
dc.date.available2023-04-04T18:12:19Z
dc.date.issued2020-06
dc.descriptionIndexación: Scopuses
dc.description.abstractBotrytis cinerea is a ubiquitous necrotrophic filamentous fungal phytopathogen that lacks host specificity and can affect more than 1000 different plant species. In this work, we explored L1 [(E)-2-{[(2-aminopyridin-2-yl)imino]-methyl}-4,6-di-tert-butylphenol], a pyridine Schiff base harboring an intramolecular bond (IHB), regarding their antifungal activity against Botrytis cinerea. Moreover, we present a full characterization of the L1 by NMR and powder diffraction, as well as UV-vis, in the presence of previously untested different organic solvents. Complementary timedependent density functional theory (TD-DFT) calculations were performed, and the noncovalent interaction (NCI) index was determined. Moreover, we obtained a scan-rate study on cyclic voltammetry of L1. Finally, we tested the antifungal activity of L1 against two strains of Botrytis cinerea (B05.10, a standard laboratory strain; and A1, a wild type strains isolated from Chilean blueberries). We found that L1 acts as an efficient antifungal agent against Botrytis cinerea at 26 °C, even better than the commercial antifungal agent fenhexamid. Although the antifungal activity was also observed at 4 °C, the effect was less pronounced. These results show the high versatility of this kind of pyridine Schiff bases in biological applications. © 2020 MDPI AG. All rights reserved.es
dc.description.urihttps://www.mdpi.com/1420-3049/25/12/2741
dc.identifier.citationMolecules Volume 25, Issue 12June 2020 Article number 2741es
dc.identifier.doi10.3390/molecules25122741
dc.identifier.issn1420-3049
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/48181
dc.language.isoenes
dc.publisherMDPIes
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectBotrytis cinereaes
dc.subjectIntramolecular hydrogen bondes
dc.subjectPyridine schiff basees
dc.titleStructural Characterization, DFT Calculation, NCI, Scan-Rate Analysis and Antifungal Activity against Botrytis cinerea of (E)-2-{[(2-Aminopyridin-2-yl)imino]-methyl}-4,6-di-tert-butylphenol (Pyridine Schiff Base)es
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