Lichens: might be considered as a source of gastroprotective molecules?

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dc.contributor.authorSepulveda, Beatriz
dc.contributor.authorChamy, María Cristina
dc.contributor.authorPiovano, Marisa
dc.contributor.authorAreche, Carlos
dc.date.accessioned2014-02-24T21:49:25Z
dc.date.accessioned2016-05-24T20:30:37Z
dc.date.available2014-02-24T21:49:25Z
dc.date.available2016-05-24T20:30:37Z
dc.date.issued2013
dc.descriptionIndexación: Web of Science; Scieloes
dc.description.abstractABSTRACT Lichens are symbiotic relationship between fungi and algae or cyanobacteria. Secondary metabolites from lichens are known as lichen substances. We investigated depsidone and depside from lichens 1-6 in the context of their action to prevent gastric ulcer on the model of HCl/ethanol in mice for the first time. Doses of 30 mg/kg of lichen substances 1-6 and positive control (lansoprazole) significantly diminished the lesion index compared with negative control (treated only with HCl/EtOH). Lobaric acid 1, atranorin 2 and psoromic acid 5 reduced the gastric lesions by 76%, 63% and 65%, while for variolaric acid 3, diffractaic acid 4 and perlatolic acid 6 their values were 32%, 14% and 45%, respectively. Our results suggest that lichens have potential as a suite of gastroprotective molecules. Keywords: Lichens; depside; depsidone; gastric ulcer;es
dc.description.urihttp://ref.scielo.org/6949f9
dc.identifier.citationJournal of the Chilean Chemical Society. Vol. 58 N° 2, 2013.es
dc.identifier.issn0717-9707
dc.identifier.otherhttp://dx.doi.org/10.4067/S0717-97072013000200024
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/2365
dc.language.isoenes
dc.subjectLichens; depside; depsidone; gastric ulcer;es
dc.titleLichens: might be considered as a source of gastroprotective molecules?es
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